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- Publisher Website: 10.1096/fj.201802306R
- Scopus: eid_2-s2.0-85067274528
- PMID: 30857422
- WOS: WOS:000476114200050
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Article: Solid-state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses
Title | Solid-state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses |
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Authors | |
Keywords | alcoholic liver disease gut microbiota metabolomics |
Issue Date | 2019 |
Citation | FASEB Journal, 2019, v. 33, n. 6, p. 7274-7288 How to Cite? |
Abstract | Alcoholic beverages, which are consumed widely in most parts of the world, have long been identified as a major risk factor for all liver diseases, particularly alcoholic liver disease (ALD). Recent compositional analyses suggest that Chinese baijiu (CB), a clear alcoholic liquid distilled from fermented grains, contains large amounts of small molecule bioactive compounds in addition to a significant amount of ethanol (EtOH). Here, in an experimental mouse model, we show that CB caused lower degrees of liver injury than pure EtOH by protecting against the decrease of the relative abundance of Akkermansia and increase of the relative abundance of Prevotella in the gut, thereby preventing the destruction of the intestinal barrier. Furthermore, we demonstrated that EtOH-induced alteration of the gut microbiota profoundly affected the host metabolome. Compared with EtOH feeding, CB feeding resulted in higher concentrations of functional saturated long-chain fatty acids and short-chain fatty acids. The additional mouse models of low dosages of EtOH and of blending baijiu validated that volatile compounds in CB can attenuate EtOH-induced liver damages. Our results provide supporting evidence that ALD was profoundly influenced by host-gut microbiota metabolic interactions and that small molecule organic compounds in CB could attenuate ALD.—Fang, C., Du, H., Zheng, X., Zhao, A., Jia, W., Xu, Y. Solid-state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses. FASEB J. 33, 7274–7288 (2019). www.fasebj.org. |
Persistent Identifier | http://hdl.handle.net/10722/342587 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fang, Cheng | - |
dc.contributor.author | Du, Hai | - |
dc.contributor.author | Zheng, Xiaojiao | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Xu, Yan | - |
dc.date.accessioned | 2024-04-17T07:04:51Z | - |
dc.date.available | 2024-04-17T07:04:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | FASEB Journal, 2019, v. 33, n. 6, p. 7274-7288 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342587 | - |
dc.description.abstract | Alcoholic beverages, which are consumed widely in most parts of the world, have long been identified as a major risk factor for all liver diseases, particularly alcoholic liver disease (ALD). Recent compositional analyses suggest that Chinese baijiu (CB), a clear alcoholic liquid distilled from fermented grains, contains large amounts of small molecule bioactive compounds in addition to a significant amount of ethanol (EtOH). Here, in an experimental mouse model, we show that CB caused lower degrees of liver injury than pure EtOH by protecting against the decrease of the relative abundance of Akkermansia and increase of the relative abundance of Prevotella in the gut, thereby preventing the destruction of the intestinal barrier. Furthermore, we demonstrated that EtOH-induced alteration of the gut microbiota profoundly affected the host metabolome. Compared with EtOH feeding, CB feeding resulted in higher concentrations of functional saturated long-chain fatty acids and short-chain fatty acids. The additional mouse models of low dosages of EtOH and of blending baijiu validated that volatile compounds in CB can attenuate EtOH-induced liver damages. Our results provide supporting evidence that ALD was profoundly influenced by host-gut microbiota metabolic interactions and that small molecule organic compounds in CB could attenuate ALD.—Fang, C., Du, H., Zheng, X., Zhao, A., Jia, W., Xu, Y. Solid-state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses. FASEB J. 33, 7274–7288 (2019). www.fasebj.org. | - |
dc.language | eng | - |
dc.relation.ispartof | FASEB Journal | - |
dc.subject | alcoholic liver disease | - |
dc.subject | gut microbiota | - |
dc.subject | metabolomics | - |
dc.title | Solid-state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1096/fj.201802306R | - |
dc.identifier.pmid | 30857422 | - |
dc.identifier.scopus | eid_2-s2.0-85067274528 | - |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 7274 | - |
dc.identifier.epage | 7288 | - |
dc.identifier.eissn | 1530-6860 | - |
dc.identifier.isi | WOS:000476114200050 | - |