File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Metabolomics-based biomarker analysis of dihydroxypropyl mercapturic acid isomers from 3-monochloropropane-1,2-diol and glycidol for evaluation of toxicokinetics in rats and daily internal exposure in humans

TitleMetabolomics-based biomarker analysis of dihydroxypropyl mercapturic acid isomers from 3-monochloropropane-1,2-diol and glycidol for evaluation of toxicokinetics in rats and daily internal exposure in humans
Authors
Keywords2,3-Dihydroxypropyl mercapturic acid
3-Monochloropropane-1,2-diol
Glycidol
Internal exposure
Isomers
Toxicokinetics
Issue Date2019
Citation
Talanta, 2019, v. 204, p. 329-336 How to Cite?
Abstract3-Monochloropropane-1,2-diol (3-MCPD), glycidol, and their esters are some major sources of risk factors during food processing. Here we showed the biomarker analysis of 2,3-dihydroxypropyl mercapturic acid (DHPMA) isomers which derived from the metabolism of 3-MCPD, glycidol, and their esters in urine of rats and humans. Iso-DHPMA, a novel urinary metabolite, was discovered and detected in urine of rats, which were orally administered with glycidol but not 3-MCPD. Using the quadrupole-orbitrap high-resolution mass spectrometry, we confirmed that iso-DHPMA appeared a specific biomarker which derived from glycidol. The limit of quantification (signal-to-noise ratio, 10:1) of the analytes in urine of rats and humans were 1.33 ng/mL and 1.56 ng/mL, respectively. Acceptable within-laboratory reproducibility (RSD<9.0%) and spiking recovery (94.7%–100.1%) substantially supported the use of current method for robust biomarker analysis, which was successfully applied to the toxicokinetic study of DHPMA in rats and short-term internal exposure to 3-MCPD and glycidol in humans.
Persistent Identifierhttp://hdl.handle.net/10722/342586
ISSN
2023 Impact Factor: 5.6
2023 SCImago Journal Rankings: 0.956
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJia, Wei-
dc.contributor.authorWu, Di-
dc.contributor.authorChen, Xinyu-
dc.contributor.authorMao, Lei-
dc.contributor.authorMiao, Hong-
dc.contributor.authorChen, Dawei-
dc.contributor.authorRen, Yiping-
dc.contributor.authorZhang, Yu-
dc.date.accessioned2024-04-17T07:04:51Z-
dc.date.available2024-04-17T07:04:51Z-
dc.date.issued2019-
dc.identifier.citationTalanta, 2019, v. 204, p. 329-336-
dc.identifier.issn0039-9140-
dc.identifier.urihttp://hdl.handle.net/10722/342586-
dc.description.abstract3-Monochloropropane-1,2-diol (3-MCPD), glycidol, and their esters are some major sources of risk factors during food processing. Here we showed the biomarker analysis of 2,3-dihydroxypropyl mercapturic acid (DHPMA) isomers which derived from the metabolism of 3-MCPD, glycidol, and their esters in urine of rats and humans. Iso-DHPMA, a novel urinary metabolite, was discovered and detected in urine of rats, which were orally administered with glycidol but not 3-MCPD. Using the quadrupole-orbitrap high-resolution mass spectrometry, we confirmed that iso-DHPMA appeared a specific biomarker which derived from glycidol. The limit of quantification (signal-to-noise ratio, 10:1) of the analytes in urine of rats and humans were 1.33 ng/mL and 1.56 ng/mL, respectively. Acceptable within-laboratory reproducibility (RSD<9.0%) and spiking recovery (94.7%–100.1%) substantially supported the use of current method for robust biomarker analysis, which was successfully applied to the toxicokinetic study of DHPMA in rats and short-term internal exposure to 3-MCPD and glycidol in humans.-
dc.languageeng-
dc.relation.ispartofTalanta-
dc.subject2,3-Dihydroxypropyl mercapturic acid-
dc.subject3-Monochloropropane-1,2-diol-
dc.subjectGlycidol-
dc.subjectInternal exposure-
dc.subjectIsomers-
dc.subjectToxicokinetics-
dc.titleMetabolomics-based biomarker analysis of dihydroxypropyl mercapturic acid isomers from 3-monochloropropane-1,2-diol and glycidol for evaluation of toxicokinetics in rats and daily internal exposure in humans-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.talanta.2019.06.009-
dc.identifier.pmid31357301-
dc.identifier.scopuseid_2-s2.0-85067015802-
dc.identifier.volume204-
dc.identifier.spage329-
dc.identifier.epage336-
dc.identifier.isiWOS:000480664200039-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats