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Article: Metabonomics Approach to Comparing the Antistress Effects of Four Panax ginseng Components in Rats

TitleMetabonomics Approach to Comparing the Antistress Effects of Four Panax ginseng Components in Rats
Authors
Keywordsginseng polysaccharide
ginsenosides
metabonomics
panaxadiol
panaxatriol
rat
stress
Issue Date2018
Citation
Journal of Proteome Research, 2018, v. 17, n. 2, p. 813-821 How to Cite?
AbstractDifferent components of Panax ginseng have different properties and medicinal effects. Metabonomics was a prospective approach to analyze the global response of endogenous metabolites to physiological and pathological processes. In this study, an untargeted metabonomics method using GC/TOFMS combined with multivariate statistical techniques was applied to compare entire metabolite differences and the antistress variations among four components of P. ginseng, namely, total ginsenosides (TG), panaxadiol (PD), panaxatriol (PT), and ginseng polysaccharide (PS), in Wistar rats. The results of metabolite analysis showed that numerous urine metabolites involving neurotransmitters, amino acids, organic acids, and gut microbiota metabolites were changed after administration of the four components of P. ginseng, with TG having the least impact on urinary metabolites. The urinary metabolite profiling of these rats exposed to acute combined stress (forced swimming and behavior restriction) demonstrated that the four ginseng components attenuated urine metabolite changes involving gut microbiota metabolites, tricarboxylic acid (TCA) cycle and energy metabolites, and organic acids to different degrees, with TG improving most of the metabolites altered by stress.
Persistent Identifierhttp://hdl.handle.net/10722/342556
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Jingcheng-
dc.contributor.authorHou, Yuanlong-
dc.contributor.authorJia, Zhiying-
dc.contributor.authorXie, Xie-
dc.contributor.authorLiu, Jiajian-
dc.contributor.authorKang, Yani-
dc.contributor.authorWang, Xin-
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:04:38Z-
dc.date.available2024-04-17T07:04:38Z-
dc.date.issued2018-
dc.identifier.citationJournal of Proteome Research, 2018, v. 17, n. 2, p. 813-821-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342556-
dc.description.abstractDifferent components of Panax ginseng have different properties and medicinal effects. Metabonomics was a prospective approach to analyze the global response of endogenous metabolites to physiological and pathological processes. In this study, an untargeted metabonomics method using GC/TOFMS combined with multivariate statistical techniques was applied to compare entire metabolite differences and the antistress variations among four components of P. ginseng, namely, total ginsenosides (TG), panaxadiol (PD), panaxatriol (PT), and ginseng polysaccharide (PS), in Wistar rats. The results of metabolite analysis showed that numerous urine metabolites involving neurotransmitters, amino acids, organic acids, and gut microbiota metabolites were changed after administration of the four components of P. ginseng, with TG having the least impact on urinary metabolites. The urinary metabolite profiling of these rats exposed to acute combined stress (forced swimming and behavior restriction) demonstrated that the four ginseng components attenuated urine metabolite changes involving gut microbiota metabolites, tricarboxylic acid (TCA) cycle and energy metabolites, and organic acids to different degrees, with TG improving most of the metabolites altered by stress.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectginseng polysaccharide-
dc.subjectginsenosides-
dc.subjectmetabonomics-
dc.subjectpanaxadiol-
dc.subjectpanaxatriol-
dc.subjectrat-
dc.subjectstress-
dc.titleMetabonomics Approach to Comparing the Antistress Effects of Four Panax ginseng Components in Rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.jproteome.7b00559-
dc.identifier.pmid29302971-
dc.identifier.scopuseid_2-s2.0-85041480036-
dc.identifier.volume17-
dc.identifier.issue2-
dc.identifier.spage813-
dc.identifier.epage821-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000424730700006-

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