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Article: Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children

TitleUrinary metabolic insights into host-gut microbial interactions in healthy and IBD children
Authors
KeywordsCrohn's disease
Growth
Inflammatory bowel disease
Metabolism
Pediatric
Phenotype
Ulcerative colitis
Issue Date2017
Citation
World Journal of Gastroenterology, 2017, v. 23, n. 20, p. 3643-3654 How to Cite?
AbstractAim: To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children. Methods: We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children. Results: urinary metabolic profiles of IBD children differ significantly from healthy controls. Such metabolic differences encompass central energy metabolism, amino acids, bile acids and gut microbial metabolites. In particular, levels of pyroglutamic acid, glutamic acid, glycine and cysteine, were significantly higher in IBD children in the course of the study. This suggests that glutathione cannot be optimally synthesized and replenished. Whilst alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known, we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier dysfunctions. Conclusion: The present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.
Persistent Identifierhttp://hdl.handle.net/10722/342541
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.063
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMartin, Francois Pierre-
dc.contributor.authorSu, Ming Ming-
dc.contributor.authorXie, Guo Xiang-
dc.contributor.authorGuiraud, Seu Ping-
dc.contributor.authorKussmann, Martin-
dc.contributor.authorGodin, Jean Philippe-
dc.contributor.authorJia, Wei-
dc.contributor.authorNydegger, Andreas-
dc.date.accessioned2024-04-17T07:04:33Z-
dc.date.available2024-04-17T07:04:33Z-
dc.date.issued2017-
dc.identifier.citationWorld Journal of Gastroenterology, 2017, v. 23, n. 20, p. 3643-3654-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/10722/342541-
dc.description.abstractAim: To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children. Methods: We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children. Results: urinary metabolic profiles of IBD children differ significantly from healthy controls. Such metabolic differences encompass central energy metabolism, amino acids, bile acids and gut microbial metabolites. In particular, levels of pyroglutamic acid, glutamic acid, glycine and cysteine, were significantly higher in IBD children in the course of the study. This suggests that glutathione cannot be optimally synthesized and replenished. Whilst alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known, we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier dysfunctions. Conclusion: The present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.-
dc.languageeng-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.subjectCrohn's disease-
dc.subjectGrowth-
dc.subjectInflammatory bowel disease-
dc.subjectMetabolism-
dc.subjectPediatric-
dc.subjectPhenotype-
dc.subjectUlcerative colitis-
dc.titleUrinary metabolic insights into host-gut microbial interactions in healthy and IBD children-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3748/wjg.v23.i20.3643-
dc.identifier.pmid28611517-
dc.identifier.scopuseid_2-s2.0-85019686289-
dc.identifier.volume23-
dc.identifier.issue20-
dc.identifier.spage3643-
dc.identifier.epage3654-
dc.identifier.eissn2219-2840-
dc.identifier.isiWOS:000402298400009-

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