File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity

TitleSerum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity
Authors
KeywordsBariatric surgery
Elovl6
Fatty acid metabolism
Targeted metabolomics
UPLC/QTOFMS
Issue Date2017
Citation
FASEB Journal, 2017, v. 31, n. 4, p. 1449-1460 How to Cite?
AbstractEndogenous fatty acidmetabolism that results inelongation and desaturation lipid products is thought to play a role in the development of type 2 diabetes mellitus (T2DM). In this study, we evaluated the potential of estimated elongase and desaturase activities for use as predictive markers for T2DM remission after Roux-en-Y gastric bypass (RYGB). The results of a targeted metabolomics approach from 2 independent studies were used to calculate 24 serum FA concentration ratios (product/precursor). Gene expression data from an open public data set was also analyzed. In a longitudinal study of 38 obese diabetic patientswithRYGB,we found higher baseline stearic acid/palmitic acid(S/P) ratio. This ratioreflects anelovl6-encodedelongase enzyme activity thathasbeenfoundtobe associated with greater possibility for diabetes remission after RYGB [odds ratio, 2.16 (95% CI 1.10-4.26)], after adjustment for age, gender, body mass index, diabetes duration, glycosylated hemoglobin A1c, and fasting C-peptide. Our results were validated by examination of postsurgical elovl6 gene expression in morbidly obese patients. The association of S/P with the metabolic status of obese individuals was further validated in a crosssectional cohort of 381 participants. In summary, higher baseline S/P was associated with greater probability of diabetes remissionafterRYGBandmay serve as adiagnosticmarker inpreoperativepatient assessment.
Persistent Identifierhttp://hdl.handle.net/10722/342537
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.412
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJia, Wei-
dc.contributor.authorZhao, Linjing-
dc.contributor.authorNi, Yan-
dc.contributor.authorYu, Haoyong-
dc.contributor.authorZhang, Pin-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorBao, Yuqian-
dc.contributor.authorLiu, Jiajian-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorXie, Guoxiang-
dc.contributor.authorPanee, Jun-
dc.contributor.authorChen, Wenlian-
dc.contributor.authorRajani, Cynthia-
dc.contributor.authorWei, Runmin-
dc.contributor.authorSu, Mingming-
dc.contributor.authorJia, Weiping-
dc.date.accessioned2024-04-17T07:04:31Z-
dc.date.available2024-04-17T07:04:31Z-
dc.date.issued2017-
dc.identifier.citationFASEB Journal, 2017, v. 31, n. 4, p. 1449-1460-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/342537-
dc.description.abstractEndogenous fatty acidmetabolism that results inelongation and desaturation lipid products is thought to play a role in the development of type 2 diabetes mellitus (T2DM). In this study, we evaluated the potential of estimated elongase and desaturase activities for use as predictive markers for T2DM remission after Roux-en-Y gastric bypass (RYGB). The results of a targeted metabolomics approach from 2 independent studies were used to calculate 24 serum FA concentration ratios (product/precursor). Gene expression data from an open public data set was also analyzed. In a longitudinal study of 38 obese diabetic patientswithRYGB,we found higher baseline stearic acid/palmitic acid(S/P) ratio. This ratioreflects anelovl6-encodedelongase enzyme activity thathasbeenfoundtobe associated with greater possibility for diabetes remission after RYGB [odds ratio, 2.16 (95% CI 1.10-4.26)], after adjustment for age, gender, body mass index, diabetes duration, glycosylated hemoglobin A1c, and fasting C-peptide. Our results were validated by examination of postsurgical elovl6 gene expression in morbidly obese patients. The association of S/P with the metabolic status of obese individuals was further validated in a crosssectional cohort of 381 participants. In summary, higher baseline S/P was associated with greater probability of diabetes remissionafterRYGBandmay serve as adiagnosticmarker inpreoperativepatient assessment.-
dc.languageeng-
dc.relation.ispartofFASEB Journal-
dc.subjectBariatric surgery-
dc.subjectElovl6-
dc.subjectFatty acid metabolism-
dc.subjectTargeted metabolomics-
dc.subjectUPLC/QTOFMS-
dc.titleSerum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1096/fj.201600927R-
dc.identifier.pmid28007782-
dc.identifier.scopuseid_2-s2.0-85017323274-
dc.identifier.volume31-
dc.identifier.issue4-
dc.identifier.spage1449-
dc.identifier.epage1460-
dc.identifier.eissn1530-6860-
dc.identifier.isiWOS:000398504300015-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats