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- Publisher Website: 10.1016/j.ccell.2016.09.006
- Scopus: eid_2-s2.0-85006489776
- PMID: 27746145
- WOS: WOS:000388064800016
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Article: Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
Title | Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential |
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Authors | |
Keywords | acute myeloid leukemia fructose utilization GLUT5 SLC2A5 |
Issue Date | 2016 |
Citation | Cancer Cell, 2016, v. 30, n. 5, p. 779-791 How to Cite? |
Abstract | Rapidly proliferating leukemic progenitor cells consume substantial glucose, which may lead to glucose insufficiency in bone marrow. We show that acute myeloid leukemia (AML) cells are prone to fructose utilization with an upregulated fructose transporter GLUT5, which compensates for glucose deficiency. Notably, AML patients with upregulated transcription of the GLUT5-encoding gene SLC2A5 or increased fructose utilization have poor outcomes. Pharmacological blockage of fructose uptake ameliorates leukemic phenotypes and potentiates the cytotoxicity of the antileukemic agent, Ara-C. In conclusion, this study highlights enhanced fructose utilization as a metabolic feature of AML and a potential therapeutic target. |
Persistent Identifier | http://hdl.handle.net/10722/342533 |
ISSN | 2023 Impact Factor: 48.8 2023 SCImago Journal Rankings: 17.507 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, Wen Lian | - |
dc.contributor.author | Wang, Yue Ying | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Xia, Li | - |
dc.contributor.author | Xie, Guoxiang | - |
dc.contributor.author | Su, Mingming | - |
dc.contributor.author | Zhao, Linjing | - |
dc.contributor.author | Liu, Jiajian | - |
dc.contributor.author | Qu, Chun | - |
dc.contributor.author | Wei, Runmin | - |
dc.contributor.author | Rajani, Cynthia | - |
dc.contributor.author | Ni, Yan | - |
dc.contributor.author | Cheng, Zhen | - |
dc.contributor.author | Chen, Zhu | - |
dc.contributor.author | Chen, Sai Juan | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:04:30Z | - |
dc.date.available | 2024-04-17T07:04:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Cancer Cell, 2016, v. 30, n. 5, p. 779-791 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342533 | - |
dc.description.abstract | Rapidly proliferating leukemic progenitor cells consume substantial glucose, which may lead to glucose insufficiency in bone marrow. We show that acute myeloid leukemia (AML) cells are prone to fructose utilization with an upregulated fructose transporter GLUT5, which compensates for glucose deficiency. Notably, AML patients with upregulated transcription of the GLUT5-encoding gene SLC2A5 or increased fructose utilization have poor outcomes. Pharmacological blockage of fructose uptake ameliorates leukemic phenotypes and potentiates the cytotoxicity of the antileukemic agent, Ara-C. In conclusion, this study highlights enhanced fructose utilization as a metabolic feature of AML and a potential therapeutic target. | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Cell | - |
dc.subject | acute myeloid leukemia | - |
dc.subject | fructose utilization | - |
dc.subject | GLUT5 | - |
dc.subject | SLC2A5 | - |
dc.title | Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ccell.2016.09.006 | - |
dc.identifier.pmid | 27746145 | - |
dc.identifier.scopus | eid_2-s2.0-85006489776 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 779 | - |
dc.identifier.epage | 791 | - |
dc.identifier.eissn | 1878-3686 | - |
dc.identifier.isi | WOS:000388064800016 | - |