File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Metabonomics approach to assessing the metabolism variation and endoexogenous metabolic interaction of ginsenosides in cold stress rats

TitleMetabonomics approach to assessing the metabolism variation and endoexogenous metabolic interaction of ginsenosides in cold stress rats
Authors
Keywordsacute cold stress
GC/MS
ginsenosides
metabonomics
UPLC-QQQ/MS
Issue Date2016
Citation
Journal of Proteome Research, 2016, v. 15, n. 6, p. 1842-1852 How to Cite?
AbstractMetabolic profiling technology, a massive information provider, has promoted the understanding of the metabolism of multicomponent medicines and its interactions with endogenous metabolites, which was previously a challenge in clarification. In this study, an untargeted GC/MS-based approach was employed to investigate the urinary metabolite profile in rats with oral administration of ginsenosides and the control group. Significant changes of urinary metabolites contents were observed in the total ginsenosides group, revealing the impact of ginsenosides as indicated by the up- or down-regulation of several pathways involving neurotransmitter-related metabolites, tricarboxylic acid (TCA) cycle, fatty acids β-oxidation, and intestinal microflora metabolites. Meanwhile, a targeted UPLC-QQQ/MS-based metabonomic approach was developed to investigate the changes of urinary ginsenoside metabolites during the process of acute cold stress. Metabolic analysis indicated that upstream ginsenosides (rg1, re, and rf) increased significantly, whereas downstream ginsenosides (ck, ppd, and ppt) decreased correspondingly after cold exposure. Finally, the relationships between ginsenosides and significantly changed metabolites were investigated by correlation analysis.
Persistent Identifierhttp://hdl.handle.net/10722/342518
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zhihao-
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorWang, Jingcheng-
dc.contributor.authorJia, Zhiying-
dc.contributor.authorLiu, Yumin-
dc.contributor.authorXie, Xie-
dc.contributor.authorWang, Chongchong-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:04:23Z-
dc.date.available2024-04-17T07:04:23Z-
dc.date.issued2016-
dc.identifier.citationJournal of Proteome Research, 2016, v. 15, n. 6, p. 1842-1852-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342518-
dc.description.abstractMetabolic profiling technology, a massive information provider, has promoted the understanding of the metabolism of multicomponent medicines and its interactions with endogenous metabolites, which was previously a challenge in clarification. In this study, an untargeted GC/MS-based approach was employed to investigate the urinary metabolite profile in rats with oral administration of ginsenosides and the control group. Significant changes of urinary metabolites contents were observed in the total ginsenosides group, revealing the impact of ginsenosides as indicated by the up- or down-regulation of several pathways involving neurotransmitter-related metabolites, tricarboxylic acid (TCA) cycle, fatty acids β-oxidation, and intestinal microflora metabolites. Meanwhile, a targeted UPLC-QQQ/MS-based metabonomic approach was developed to investigate the changes of urinary ginsenoside metabolites during the process of acute cold stress. Metabolic analysis indicated that upstream ginsenosides (rg1, re, and rf) increased significantly, whereas downstream ginsenosides (ck, ppd, and ppt) decreased correspondingly after cold exposure. Finally, the relationships between ginsenosides and significantly changed metabolites were investigated by correlation analysis.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectacute cold stress-
dc.subjectGC/MS-
dc.subjectginsenosides-
dc.subjectmetabonomics-
dc.subjectUPLC-QQQ/MS-
dc.titleMetabonomics approach to assessing the metabolism variation and endoexogenous metabolic interaction of ginsenosides in cold stress rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.jproteome.6b00015-
dc.identifier.pmid27150950-
dc.identifier.scopuseid_2-s2.0-84973514543-
dc.identifier.volume15-
dc.identifier.issue6-
dc.identifier.spage1842-
dc.identifier.epage1852-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000377319200011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats