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Article: The influence of gut microbiota on drug metabolism and toxicity

TitleThe influence of gut microbiota on drug metabolism and toxicity
Authors
Keywordsdrug metabolism
efficacy
gut microbiota
toxicity
Issue Date2016
Citation
Expert Opinion on Drug Metabolism and Toxicology, 2016, v. 12, n. 1, p. 31-40 How to Cite?
AbstractIntroduction: Gut microbiota plays critical roles in drug metabolism. The variation of gut microbiota contributes to the interindividual differences toward drug therapy including drug-induced toxicity and efficacy. Accordingly, the investigation and elucidation of gut microbial impacts on drug metabolism and toxicity will not only facilitate the way of personalized medicine, but also improve rational drug design.Areas covered: This review provides an overview of the microbiota-host co-metabolism on drug metabolism and summarizes 30 clinical drugs that are co-metabolized by host and gut microbiota. Moreover, this review is specifically focused on elucidating the gut microbial modulation of some clinical drugs, in which the gut microbial influences on drug metabolism, drug-induced toxicity and efficacy are discussed.Expert opinion: The gut microbial contribution to drug metabolism and toxicity is increasingly recognized, but remains largely unexplored due to the extremely complex relationship between gut microbiota and host. The mechanistic elucidation of gut microbiota in drug metabolism is critical before any practical progress in drug design or personalized medicine could be made by modulating human gut microbiota. Analytical technique innovation is urgently required to strengthen our capability in recognizing microbial functions, including metagenomics, metabolomics and the integration of multidisciplinary knowledge.
Persistent Identifierhttp://hdl.handle.net/10722/342506
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 0.987
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Houkai-
dc.contributor.authorHe, Jiaojiao-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:04:18Z-
dc.date.available2024-04-17T07:04:18Z-
dc.date.issued2016-
dc.identifier.citationExpert Opinion on Drug Metabolism and Toxicology, 2016, v. 12, n. 1, p. 31-40-
dc.identifier.issn1742-5255-
dc.identifier.urihttp://hdl.handle.net/10722/342506-
dc.description.abstractIntroduction: Gut microbiota plays critical roles in drug metabolism. The variation of gut microbiota contributes to the interindividual differences toward drug therapy including drug-induced toxicity and efficacy. Accordingly, the investigation and elucidation of gut microbial impacts on drug metabolism and toxicity will not only facilitate the way of personalized medicine, but also improve rational drug design.Areas covered: This review provides an overview of the microbiota-host co-metabolism on drug metabolism and summarizes 30 clinical drugs that are co-metabolized by host and gut microbiota. Moreover, this review is specifically focused on elucidating the gut microbial modulation of some clinical drugs, in which the gut microbial influences on drug metabolism, drug-induced toxicity and efficacy are discussed.Expert opinion: The gut microbial contribution to drug metabolism and toxicity is increasingly recognized, but remains largely unexplored due to the extremely complex relationship between gut microbiota and host. The mechanistic elucidation of gut microbiota in drug metabolism is critical before any practical progress in drug design or personalized medicine could be made by modulating human gut microbiota. Analytical technique innovation is urgently required to strengthen our capability in recognizing microbial functions, including metagenomics, metabolomics and the integration of multidisciplinary knowledge.-
dc.languageeng-
dc.relation.ispartofExpert Opinion on Drug Metabolism and Toxicology-
dc.subjectdrug metabolism-
dc.subjectefficacy-
dc.subjectgut microbiota-
dc.subjecttoxicity-
dc.titleThe influence of gut microbiota on drug metabolism and toxicity-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1517/17425255.2016.1121234-
dc.identifier.pmid26569070-
dc.identifier.scopuseid_2-s2.0-84954379199-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spage31-
dc.identifier.epage40-
dc.identifier.eissn1744-7607-
dc.identifier.isiWOS:000367832900002-

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