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Article: Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population

TitleSerum trace element differences between Schizophrenia patients and controls in the Han Chinese population
Authors
Issue Date2015
Citation
Scientific Reports, 2015, v. 5, article no. 15013 How to Cite?
AbstractLittle is known about the trace element profile differences between Schizophrenia patients and healthy controls; previous studies about the association of certain elements with Schizophrenia have obtained conflicting results. To identify these differences in the Han Chinese population, inductively coupled plasma-mass spectrometry was used to quantify the levels of 35 elements in the sera of 111 Schizophrenia patients and 110 healthy participants, which consisted of a training (61/61 for cases/controls included) and a test group including remaining participants. An orthogonal projection to latent structures model was constructed from the training group (R2Y = 0.465, Q2cum = 0.343) had a sensitivity of 76.0% and a specificity of 71.4% in the test group. Single element analysis indicated that the concentrations of cesium, zinc, and selenium were significantly reduced in patients with Schizophrenia in both the training and test groups. The meta-analysis including 522 cases and 360 controls supported that Zinc was significantly associated with Schizophrenia (standardized mean difference [SMD],-0.81; 95% confidence intervals [CI],-1.46 to-0.16, P = 0.01) in the randomeffect model. Information theory analysis indicated that Zinc could play roles independently in Schizophrenia. These results suggest clear element profile differences between patients with Schizophrenia and healthy controls, and reduced Zn level is confirmed in the Schizophrenia patients.
Persistent Identifierhttp://hdl.handle.net/10722/342497
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCai, Lei-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorYang, Jinglei-
dc.contributor.authorZhou, Kejun-
dc.contributor.authorYan, Xiaomei-
dc.contributor.authorChen, Wenzhong-
dc.contributor.authorSun, Liya-
dc.contributor.authorLi, Linlin-
dc.contributor.authorQin, Shengying-
dc.contributor.authorWang, Peng-
dc.contributor.authorYang, Ping-
dc.contributor.authorCui, Donghong-
dc.contributor.authorBurmeister, Margit-
dc.contributor.authorHe, Lin-
dc.contributor.authorJia, Wei-
dc.contributor.authorWan, Chunling-
dc.date.accessioned2024-04-17T07:04:14Z-
dc.date.available2024-04-17T07:04:14Z-
dc.date.issued2015-
dc.identifier.citationScientific Reports, 2015, v. 5, article no. 15013-
dc.identifier.urihttp://hdl.handle.net/10722/342497-
dc.description.abstractLittle is known about the trace element profile differences between Schizophrenia patients and healthy controls; previous studies about the association of certain elements with Schizophrenia have obtained conflicting results. To identify these differences in the Han Chinese population, inductively coupled plasma-mass spectrometry was used to quantify the levels of 35 elements in the sera of 111 Schizophrenia patients and 110 healthy participants, which consisted of a training (61/61 for cases/controls included) and a test group including remaining participants. An orthogonal projection to latent structures model was constructed from the training group (R2Y = 0.465, Q2cum = 0.343) had a sensitivity of 76.0% and a specificity of 71.4% in the test group. Single element analysis indicated that the concentrations of cesium, zinc, and selenium were significantly reduced in patients with Schizophrenia in both the training and test groups. The meta-analysis including 522 cases and 360 controls supported that Zinc was significantly associated with Schizophrenia (standardized mean difference [SMD],-0.81; 95% confidence intervals [CI],-1.46 to-0.16, P = 0.01) in the randomeffect model. Information theory analysis indicated that Zinc could play roles independently in Schizophrenia. These results suggest clear element profile differences between patients with Schizophrenia and healthy controls, and reduced Zn level is confirmed in the Schizophrenia patients.-
dc.languageeng-
dc.relation.ispartofScientific Reports-
dc.titleSerum trace element differences between Schizophrenia patients and controls in the Han Chinese population-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/srep15013-
dc.identifier.pmid26456296-
dc.identifier.scopuseid_2-s2.0-84943809850-
dc.identifier.volume5-
dc.identifier.spagearticle no. 15013-
dc.identifier.epagearticle no. 15013-
dc.identifier.eissn2045-2322-
dc.identifier.isiWOS:000362557500001-

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