Comparative study of main components of ginseng on immune function of rats

Abstract

Ginseng and ifs effective components are famous for their influence to enhance human immunity, regulate endocrine and antioxidant action. However, the different effects of different components are not clear. In this study, Wistar rats were used to study the effects of main components of ginsei g, including total ginsenoside, panaxadiol saponins, panaxtrol saponin and ginseng polysaccharide. The results showed that the' effects of panaxadiol saponins and ginseng polysaccharide on improving animal immune organ weight, plasma interleukin 2 ( IL-2) , interlei kin 6 ( IL-6), plasma gam ma-interferon ( IFN-γ) , tumor necrosis factor alpha (TNK-α) were better than that of the other groups. Total ginsenoside and panaxtrol saponin can effectively increase the concentration of spleen Nk cells ( NKG) while panaxadiol saponins and ginseng polysaccharide can significantly increase the concentrations of rat plasma adrenocorticotropic hormone (AGT1I), corticosterone (CORT) and thyroid stimulating honnone (TSII). As for the effect of increasing organization nitric oxide (NO) and superoxide dismutase (SOD), glutathione (GSII) and malondialdehyde (MDA) , total ginsenoside is better than that of other groups. In brief, different components in ginseng jxjssess different effects on enhancing immunity , regulating endocrine and resisting oxidation. Panaxadiol saponins and ginseng polysaccharide are better in enhancing immune, and total ginsenoside shows advantages in resisting oxidation and stress.