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Article: Metabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using GC/TOF MS

TitleMetabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using GC/TOF MS
Authors
Issue Date2013
Citation
Evidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 540957 How to Cite?
AbstractKidney Yang Deficiency Syndrome (KDS-Yang), a typical condition in Chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome. To date, the underlying mechanism of KDS-Yang has been remained unclear, especially at the metabolic level. In this study, we report a metabolomic profiling study on a classical model of KDS-Yang in rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry. WKY1, a polysaccharide extract from Astragalus membranaceus and Lycium barbarum, and WKY2, an aqueous extract from a similar formula containing Astragalus membranaceus, Lycium barbarum, Morinda officinalis, Taraxacum mongolicum, and Cinnamomum cassia presl, were used separately for protective treatments of KDS-Yang. The changes of serum metabolic profiles indicated that significant alterations of key metabolic pathways in response to abrupt hydrocortisone perturbation, including decreased energy metabolism (lactic acid, acetylcarnitine), lipid metabolism (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), biosynthesis of catecholamine (norepinephrine), and elevated alanine metabolism, were attenuated or normalized with different degrees by the pretreatment of WKY1 or WKY2, which is consistent with the observations in which the two herbal agents could ameliorate biochemical markers of serum cortisone, adrenocorticotropic (ACTH), and urine 17- hydroxycorticosteroids (17-OHCS). © 2013 Linjing Zhao et al.
Persistent Identifierhttp://hdl.handle.net/10722/342456
ISSN
2021 Impact Factor: 2.650
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Linjing-
dc.contributor.authorWu, Hongbing-
dc.contributor.authorQiu, Mingfeng-
dc.contributor.authorSun, Wei-
dc.contributor.authorWei, Runmin-
dc.contributor.authorZheng, Xiaojiao-
dc.contributor.authorYang, Yiting-
dc.contributor.authorXin, Xue-
dc.contributor.authorZou, Haimiao-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorLiu, Jiajian-
dc.contributor.authorLu, Lina-
dc.contributor.authorSu, Jing-
dc.contributor.authorMa, Chungwah-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:57Z-
dc.date.available2024-04-17T07:03:57Z-
dc.date.issued2013-
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 540957-
dc.identifier.issn1741-427X-
dc.identifier.urihttp://hdl.handle.net/10722/342456-
dc.description.abstractKidney Yang Deficiency Syndrome (KDS-Yang), a typical condition in Chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome. To date, the underlying mechanism of KDS-Yang has been remained unclear, especially at the metabolic level. In this study, we report a metabolomic profiling study on a classical model of KDS-Yang in rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry. WKY1, a polysaccharide extract from Astragalus membranaceus and Lycium barbarum, and WKY2, an aqueous extract from a similar formula containing Astragalus membranaceus, Lycium barbarum, Morinda officinalis, Taraxacum mongolicum, and Cinnamomum cassia presl, were used separately for protective treatments of KDS-Yang. The changes of serum metabolic profiles indicated that significant alterations of key metabolic pathways in response to abrupt hydrocortisone perturbation, including decreased energy metabolism (lactic acid, acetylcarnitine), lipid metabolism (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), biosynthesis of catecholamine (norepinephrine), and elevated alanine metabolism, were attenuated or normalized with different degrees by the pretreatment of WKY1 or WKY2, which is consistent with the observations in which the two herbal agents could ameliorate biochemical markers of serum cortisone, adrenocorticotropic (ACTH), and urine 17- hydroxycorticosteroids (17-OHCS). © 2013 Linjing Zhao et al.-
dc.languageeng-
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine-
dc.titleMetabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using GC/TOF MS-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1155/2013/540957-
dc.identifier.scopuseid_2-s2.0-84885358240-
dc.identifier.volume2013-
dc.identifier.spagearticle no. 540957-
dc.identifier.epagearticle no. 540957-
dc.identifier.eissn1741-4288-
dc.identifier.isiWOS:000324773400001-

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