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Article: Metabolomic profiling in colorectal cancer: Opportunities for personalized medicine
Title | Metabolomic profiling in colorectal cancer: Opportunities for personalized medicine |
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Authors | |
Keywords | Biomarkers Colorectal cancer Drug discovery Early diagnosis Metabolomic profiling Personalized medicine Staging Treatment |
Issue Date | 2013 |
Citation | Personalized Medicine, 2013, v. 10, n. 7, p. 741-755 How to Cite? |
Abstract | Colorectal cancer (CRC) is one of the most common types of cancer in the world, with high prevalence and mortality. Understanding the alterations of cancer metabolism and identifying reliable biomarkers would facilitate the development of novel technologies of CRC screening and early diagnosis, as well as new approaches to providing personalized medicine. Metabolomics, as an emerging molecular phenotyping approach, provides a clinical platform technology with an unprecedented amount of metabolic readout information, which is ideal for theranostic biomarker discovery. Metabolic signatures can link the unique pathophysiological states of patients to personalized health monitoring and intervention strategies. This article presents an overview of the metabolomic studies of CRC with a focus on recent advances in the biomarker discovery in serum, urine, fecal water and tissue samples for cancer diagnosis. The development and application of metabolomics towards personalized medicine, including early diagnosis, cancer staging, treatment and drug discovery are also discussed. © 2013 Future Medicine Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/342454 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Xiaojiao | - |
dc.contributor.author | Xie, Guoxiang | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:03:56Z | - |
dc.date.available | 2024-04-17T07:03:56Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Personalized Medicine, 2013, v. 10, n. 7, p. 741-755 | - |
dc.identifier.issn | 1741-0541 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342454 | - |
dc.description.abstract | Colorectal cancer (CRC) is one of the most common types of cancer in the world, with high prevalence and mortality. Understanding the alterations of cancer metabolism and identifying reliable biomarkers would facilitate the development of novel technologies of CRC screening and early diagnosis, as well as new approaches to providing personalized medicine. Metabolomics, as an emerging molecular phenotyping approach, provides a clinical platform technology with an unprecedented amount of metabolic readout information, which is ideal for theranostic biomarker discovery. Metabolic signatures can link the unique pathophysiological states of patients to personalized health monitoring and intervention strategies. This article presents an overview of the metabolomic studies of CRC with a focus on recent advances in the biomarker discovery in serum, urine, fecal water and tissue samples for cancer diagnosis. The development and application of metabolomics towards personalized medicine, including early diagnosis, cancer staging, treatment and drug discovery are also discussed. © 2013 Future Medicine Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Personalized Medicine | - |
dc.subject | Biomarkers | - |
dc.subject | Colorectal cancer | - |
dc.subject | Drug discovery | - |
dc.subject | Early diagnosis | - |
dc.subject | Metabolomic profiling | - |
dc.subject | Personalized medicine | - |
dc.subject | Staging | - |
dc.subject | Treatment | - |
dc.title | Metabolomic profiling in colorectal cancer: Opportunities for personalized medicine | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2217/pme.13.73 | - |
dc.identifier.scopus | eid_2-s2.0-84884130766 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 741 | - |
dc.identifier.epage | 755 | - |
dc.identifier.eissn | 1744-828X | - |
dc.identifier.isi | WOS:000337184100015 | - |