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Article: Novel biomarkers of hyperlipidemic acute pancreatitis: Metabolomic identification

TitleNovel biomarkers of hyperlipidemic acute pancreatitis: Metabolomic identification
Authors
KeywordsBlood
Hyperlipidemic pancreatitis
Metabolism
Urine
Issue Date2012
Citation
Asian Biomedicine, 2012, v. 6, n. 5, p. 765-769 How to Cite?
AbstractBackground: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of therapy. Objective: Investigate metabolic profiling technologies for identifying novel biomarkers and pathways activated in HLP. Methods: Blood and urine samples were obtained from 24 patients and 39 healthy people. A gas chromatography and mass spectrometry was employed to study the metabolic profile in HLP and healthy groups. Functional pathway trend analysis using multivariate statistical analysis was performed. Results: HLP patients could be precisely distinguished from the healthy controls. In the patient, levels of aconitate, citrate, hippurate, p-hydroxyphenylacetate and p-hydroxyphenylpopionic acid were decreased, while levels of tryptophan, tyrosine, tyramine,16-hexadecanoic acid, and 18-octadecanoic acid were increased. The change of energy metabolism-related mechanisms, fatty acid metabolism, gut microbiota metabolism, and metabolism of tyrosine could be used to distinguish HLP patients. Conclusions: Novel biomarkers could be identified by application of metabolomics. Metabolic profiling was useful for studies of pathogenesis of HLP.
Persistent Identifierhttp://hdl.handle.net/10722/342437
ISSN
2023 Impact Factor: 0.4
2023 SCImago Journal Rankings: 0.155
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Yan-
dc.contributor.authorJia, Wei-
dc.contributor.authorSu, Mingming-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorWang, Xingpeng-
dc.date.accessioned2024-04-17T07:03:49Z-
dc.date.available2024-04-17T07:03:49Z-
dc.date.issued2012-
dc.identifier.citationAsian Biomedicine, 2012, v. 6, n. 5, p. 765-769-
dc.identifier.issn1905-7415-
dc.identifier.urihttp://hdl.handle.net/10722/342437-
dc.description.abstractBackground: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of therapy. Objective: Investigate metabolic profiling technologies for identifying novel biomarkers and pathways activated in HLP. Methods: Blood and urine samples were obtained from 24 patients and 39 healthy people. A gas chromatography and mass spectrometry was employed to study the metabolic profile in HLP and healthy groups. Functional pathway trend analysis using multivariate statistical analysis was performed. Results: HLP patients could be precisely distinguished from the healthy controls. In the patient, levels of aconitate, citrate, hippurate, p-hydroxyphenylacetate and p-hydroxyphenylpopionic acid were decreased, while levels of tryptophan, tyrosine, tyramine,16-hexadecanoic acid, and 18-octadecanoic acid were increased. The change of energy metabolism-related mechanisms, fatty acid metabolism, gut microbiota metabolism, and metabolism of tyrosine could be used to distinguish HLP patients. Conclusions: Novel biomarkers could be identified by application of metabolomics. Metabolic profiling was useful for studies of pathogenesis of HLP.-
dc.languageeng-
dc.relation.ispartofAsian Biomedicine-
dc.subjectBlood-
dc.subjectHyperlipidemic pancreatitis-
dc.subjectMetabolism-
dc.subjectUrine-
dc.titleNovel biomarkers of hyperlipidemic acute pancreatitis: Metabolomic identification-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.5372/1905-7415.0605.119-
dc.identifier.scopuseid_2-s2.0-84874610222-
dc.identifier.volume6-
dc.identifier.issue5-
dc.identifier.spage765-
dc.identifier.epage769-
dc.identifier.eissn1875-855X-
dc.identifier.isiWOS:000311922200016-

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