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Article: Human gouty arthritis is associated with a distinct serum trace elemental profile

TitleHuman gouty arthritis is associated with a distinct serum trace elemental profile
Authors
Issue Date2012
Citation
Metallomics, 2012, v. 4, n. 3, p. 244-252 How to Cite?
AbstractHomeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors. © 2012 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/342421
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.706
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSu, Mingming-
dc.contributor.authorZhang, Ting-
dc.contributor.authorZhao, Tie-
dc.contributor.authorLi, Fen-
dc.contributor.authorNi, Yan-
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorBao, Yuqian-
dc.contributor.authorJie, Weiping-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:42Z-
dc.date.available2024-04-17T07:03:42Z-
dc.date.issued2012-
dc.identifier.citationMetallomics, 2012, v. 4, n. 3, p. 244-252-
dc.identifier.issn1756-5901-
dc.identifier.urihttp://hdl.handle.net/10722/342421-
dc.description.abstractHomeostatic imbalance of essential trace elements is deeply involved in many pathophysiological states, especially in joint disorders such as gout. A total of 64 elements were measured in the serum samples in three regionally independent groups of patients with gouty arthritis (n = 100) and an age-matched healthy control group (n = 40) by inductively coupled plasma-mass spectrometry (ICP-MS). A distinct elemental profile of gouty arthritis encompassing significantly altered Li, Al, Ti, Fe, Cu, Se, Sr, Ta, Hg, Bi, Th, and U was obtained with a sensitivity of 0.97 (95% confidence interval (CI): 0.92-0.99) and a specificity of 0.95 (95% CI: 0.83-0.99) for gout diagnosis. An independent group of 52 subjects (39 gout patients and 13 healthy controls) was further used to validate the elemental signature, yielding a sensitivity of 1.00 (95% CI: 0.91-1.00) and a specificity of 1.00 (95% CI: 0.75-1.00) for gout prediction. It is also noteworthy that we were able to achieve ≥95.7% correct classification rate in both discovery and validation groups using only three elemental markers, Li, Al, and U. We also observed a good correlation between Li, Zn, and Cu and the other two risk factors, age and serum urate concentration, in gout patients. Our findings underscore that gouty arthritis possesses a unique elemental expression profile regardless of many other nutritional and environmental factors. © 2012 The Royal Society of Chemistry.-
dc.languageeng-
dc.relation.ispartofMetallomics-
dc.titleHuman gouty arthritis is associated with a distinct serum trace elemental profile-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c2mt00178k-
dc.identifier.pmid22258548-
dc.identifier.scopuseid_2-s2.0-84863273758-
dc.identifier.volume4-
dc.identifier.issue3-
dc.identifier.spage244-
dc.identifier.epage252-
dc.identifier.eissn1756-591X-
dc.identifier.isiWOS:000300886700002-

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