File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The footprints of gut microbial-mammalian co-metabolism

TitleThe footprints of gut microbial-mammalian co-metabolism
Authors
Keywordsantibiotics
gut microbial-mammalian co-metabolism
mass spectrometry
metabolomics
metabonomics
metagenomics
microbiome
Issue Date2011
Citation
Journal of Proteome Research, 2011, v. 10, n. 12, p. 5512-5522 How to Cite?
AbstractGut microbiota are associated with essential various biological functions in humans through a "network" of microbial-host co-metabolism to process nutrients and drugs and modulate the activities of multiple pathways in organ systems that are linked to different diseases. The microbiome impacts strongly on the metabolic phenotypes of the host, and hence, metabolic readouts can give insights into functional metagenomic activity. We applied an untargeted mass spectrometry (MS) based metabonomics approach to profile normal Wistar rats exposed to a broad spectrum β-lactam antibiotic imipenem/cilastatin sodium, at 50 mg/kg/daily for 4 days followed by a 14-day recovery period. In-depth metabolic phenotyping allowed identification of a panel of 202 urinary and 223 fecal metabolites significantly related to end points of a functional metagenome (p < 0.05 in at least one day), many of which have not been previously reported such as oligopeptides and carbohydrates. This study shows extensive gut microbiota modulation of host systemic metabolism involving short-chain fatty acids, tryptophan, tyrosine metabolism, and possibly a compensatory mechanism of indole-melatonin production. Given the integral nature of the mammalian genome and metagenome, this panel of metabolites will provide a new platform for potential therapeutic markers and mechanistic solutions to complex problems commonly encountered in pathology, toxicology, or drug metabolism studies. © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342402
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZheng, Xiaojiao-
dc.contributor.authorXie, Guoxiang-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorZhao, Linjing-
dc.contributor.authorYao, Chun-
dc.contributor.authorChiu, Norman H.L.-
dc.contributor.authorZhou, Zhanxiang-
dc.contributor.authorBao, Yuqian-
dc.contributor.authorJia, Weiping-
dc.contributor.authorNicholson, Jeremy K.-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:33Z-
dc.date.available2024-04-17T07:03:33Z-
dc.date.issued2011-
dc.identifier.citationJournal of Proteome Research, 2011, v. 10, n. 12, p. 5512-5522-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342402-
dc.description.abstractGut microbiota are associated with essential various biological functions in humans through a "network" of microbial-host co-metabolism to process nutrients and drugs and modulate the activities of multiple pathways in organ systems that are linked to different diseases. The microbiome impacts strongly on the metabolic phenotypes of the host, and hence, metabolic readouts can give insights into functional metagenomic activity. We applied an untargeted mass spectrometry (MS) based metabonomics approach to profile normal Wistar rats exposed to a broad spectrum β-lactam antibiotic imipenem/cilastatin sodium, at 50 mg/kg/daily for 4 days followed by a 14-day recovery period. In-depth metabolic phenotyping allowed identification of a panel of 202 urinary and 223 fecal metabolites significantly related to end points of a functional metagenome (p < 0.05 in at least one day), many of which have not been previously reported such as oligopeptides and carbohydrates. This study shows extensive gut microbiota modulation of host systemic metabolism involving short-chain fatty acids, tryptophan, tyrosine metabolism, and possibly a compensatory mechanism of indole-melatonin production. Given the integral nature of the mammalian genome and metagenome, this panel of metabolites will provide a new platform for potential therapeutic markers and mechanistic solutions to complex problems commonly encountered in pathology, toxicology, or drug metabolism studies. © 2011 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectantibiotics-
dc.subjectgut microbial-mammalian co-metabolism-
dc.subjectmass spectrometry-
dc.subjectmetabolomics-
dc.subjectmetabonomics-
dc.subjectmetagenomics-
dc.subjectmicrobiome-
dc.titleThe footprints of gut microbial-mammalian co-metabolism-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr2007945-
dc.identifier.pmid21970572-
dc.identifier.scopuseid_2-s2.0-82755184864-
dc.identifier.volume10-
dc.identifier.issue12-
dc.identifier.spage5512-
dc.identifier.epage5522-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000297537200023-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats