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- Publisher Website: 10.1007/s11306-011-0276-5
- Scopus: eid_2-s2.0-80054051929
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Article: Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice
Title | Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice |
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Authors | |
Keywords | Developmental toxicity Di-n-butyl phthalate Gas chromatography time-of-flight mass spectrometry Metabolomics Neural tube defects |
Issue Date | 2011 |
Citation | Metabolomics, 2011, v. 7, n. 4, p. 559-571 How to Cite? |
Abstract | Di-n-butyl phthalate (DBP) has been linked to the neural, reproductive and developmental toxicity. We present here a metabolomic study that characterized the metabolic variations associated with the DBP-induced teratogenesis in maternal and fetal mice. DBP at 50 and 300 mg/kg were administrated to pregnant C57 mice, via gastric intubation on gestation day 7-9, respectively. Maternal mice were euthanized on gestation day 16 and examined for fetal development and malformations. Metabolomic study of maternal serum, placenta and fetal brain tissues was performed using gas chromatography time-of-flight mass spectrometry combined with multivariate data analysis (MVDA). The results showed that a 50 mg/kg dose of DBP had no significant effect on fetal development and a 300 mg/kg dose caused embryo resorption and fetal malformations (primarily eye abnormalities and encephalocele). MVDA indicated that DBP at two doses gave rise to disruption of maternal and fetal metabolic profiles characterized by significantly altered tricarboxylic acid cycle, amino acid, purine and lipid metabolism. © 2011 Springer Science+Business Media, LLC. |
Persistent Identifier | http://hdl.handle.net/10722/342396 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.740 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xia, Hongfei | - |
dc.contributor.author | Chi, Yi | - |
dc.contributor.author | Qi, Xin | - |
dc.contributor.author | Su, Mingming | - |
dc.contributor.author | Cao, Yu | - |
dc.contributor.author | Song, Peipei | - |
dc.contributor.author | Li, Xin | - |
dc.contributor.author | Chen, Tianlu | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Zhang, Yinan | - |
dc.contributor.author | Cao, Yi | - |
dc.contributor.author | Ma, Xu | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:03:31Z | - |
dc.date.available | 2024-04-17T07:03:31Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Metabolomics, 2011, v. 7, n. 4, p. 559-571 | - |
dc.identifier.issn | 1573-3882 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342396 | - |
dc.description.abstract | Di-n-butyl phthalate (DBP) has been linked to the neural, reproductive and developmental toxicity. We present here a metabolomic study that characterized the metabolic variations associated with the DBP-induced teratogenesis in maternal and fetal mice. DBP at 50 and 300 mg/kg were administrated to pregnant C57 mice, via gastric intubation on gestation day 7-9, respectively. Maternal mice were euthanized on gestation day 16 and examined for fetal development and malformations. Metabolomic study of maternal serum, placenta and fetal brain tissues was performed using gas chromatography time-of-flight mass spectrometry combined with multivariate data analysis (MVDA). The results showed that a 50 mg/kg dose of DBP had no significant effect on fetal development and a 300 mg/kg dose caused embryo resorption and fetal malformations (primarily eye abnormalities and encephalocele). MVDA indicated that DBP at two doses gave rise to disruption of maternal and fetal metabolic profiles characterized by significantly altered tricarboxylic acid cycle, amino acid, purine and lipid metabolism. © 2011 Springer Science+Business Media, LLC. | - |
dc.language | eng | - |
dc.relation.ispartof | Metabolomics | - |
dc.subject | Developmental toxicity | - |
dc.subject | Di-n-butyl phthalate | - |
dc.subject | Gas chromatography time-of-flight mass spectrometry | - |
dc.subject | Metabolomics | - |
dc.subject | Neural tube defects | - |
dc.title | Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s11306-011-0276-5 | - |
dc.identifier.scopus | eid_2-s2.0-80054051929 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 559 | - |
dc.identifier.epage | 571 | - |
dc.identifier.eissn | 1573-3890 | - |
dc.identifier.isi | WOS:000295991900010 | - |