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Article: Serum and urinary metabonomic study of human osteosarcoma

TitleSerum and urinary metabonomic study of human osteosarcoma
Authors
Keywordsgas chromatography-mass spectrometry
metabolomics
metabonomics
osteosarcoma
serum
urine
Issue Date2010
Citation
Journal of Proteome Research, 2010, v. 9, n. 9, p. 4861-4868 How to Cite?
AbstractOsteosarcoma (OS) is the most common malignant bone tumor found in children. Currently, researchers have focused on protein and gene levels, while the associated metabolic variations have been poorly understood. In this study, we used a gas chromatography mass spectrometry approach and profiled small-molecule metabolites in serum and urine of 24 OS patients, 19 benign bone tumor patients, and 32 healthy controls, to determine whether there are significant alterations associated with carcinogenesis. The metabonomic results demonstrate clear intergroup separations between healthy control subjects and bone tumor patients in the orthogonal partial least-squares-discriminant analysis (OPLS-DA) models. Differential metabolites identified from the metabonomic analysis suggest a disrupted energy metabolism in OS patients, as characterized by significantly down-regulated TCA cycle and glycolysis, down-regulated lipid metabolism, dysregulated sugar levels, and up-regulated amino acid metabolism. Additionally, an increased activity of glutathione metabolism, and increased polyamine metabolism also contributed to a characteristic metabolic signature of OS patients. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342380
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zhiyu-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorHua, Yingqi-
dc.contributor.authorWang, Yihuang-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorChi, Yi-
dc.contributor.authorPan, Li-
dc.contributor.authorHu, Shuo-
dc.contributor.authorLi, Jian-
dc.contributor.authorYang, Chengwei-
dc.contributor.authorLi, Guodong-
dc.contributor.authorSun, Wei-
dc.contributor.authorCai, Zhengdong-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:25Z-
dc.date.available2024-04-17T07:03:25Z-
dc.date.issued2010-
dc.identifier.citationJournal of Proteome Research, 2010, v. 9, n. 9, p. 4861-4868-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342380-
dc.description.abstractOsteosarcoma (OS) is the most common malignant bone tumor found in children. Currently, researchers have focused on protein and gene levels, while the associated metabolic variations have been poorly understood. In this study, we used a gas chromatography mass spectrometry approach and profiled small-molecule metabolites in serum and urine of 24 OS patients, 19 benign bone tumor patients, and 32 healthy controls, to determine whether there are significant alterations associated with carcinogenesis. The metabonomic results demonstrate clear intergroup separations between healthy control subjects and bone tumor patients in the orthogonal partial least-squares-discriminant analysis (OPLS-DA) models. Differential metabolites identified from the metabonomic analysis suggest a disrupted energy metabolism in OS patients, as characterized by significantly down-regulated TCA cycle and glycolysis, down-regulated lipid metabolism, dysregulated sugar levels, and up-regulated amino acid metabolism. Additionally, an increased activity of glutathione metabolism, and increased polyamine metabolism also contributed to a characteristic metabolic signature of OS patients. © 2010 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectgas chromatography-mass spectrometry-
dc.subjectmetabolomics-
dc.subjectmetabonomics-
dc.subjectosteosarcoma-
dc.subjectserum-
dc.subjecturine-
dc.titleSerum and urinary metabonomic study of human osteosarcoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr100480r-
dc.identifier.pmid20690664-
dc.identifier.scopuseid_2-s2.0-77956308261-
dc.identifier.volume9-
dc.identifier.issue9-
dc.identifier.spage4861-
dc.identifier.epage4868-
dc.identifier.eissn1535-3907-
dc.identifier.isiWOS:000281443700049-

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