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- Publisher Website: 10.1021/pr900333h
- Scopus: eid_2-s2.0-73649128909
- PMID: 19476335
- WOS: WOS:000273267900013
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Article: Metabonomic evaluation of melamine-induced acute renal toxicity in rats
Title | Metabonomic evaluation of melamine-induced acute renal toxicity in rats |
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Authors | |
Keywords | Cyanuric acid Melamine Metabonomics Multivariate statistical analysis Nephrotoxicity Ultraperformance liquid chromatography/ time-of-flight mass spectrometry Urine |
Issue Date | 2010 |
Citation | Journal of Proteome Research, 2010, v. 9, n. 1, p. 125-133 How to Cite? |
Abstract | The recent outbreak of renal failure in infants in China has been determined to be caused by melamine (Mel) and derivatives adulterated in the food. A metabonomic study was performed to evaluate the global biochemical alteration triggered by Mel ingestion in parallel with the acute renal toxicity in rats. Mel at 600, 300, and 100 mg/kg, cyanuric acid (Cya) at 100 mg/kg, and mixture of Mel and Cya (50 mg/kg each) were administered in five groups of Wistar rats, respectively, via oral gavage for 15 days. Urinary metabonomic profiles indicated that Mel perturbed urinary metabolism in a dose-dependent manner, with high-dose group showing the most significant impact. Metabonomic variations also suggest that the toxicity of low-dose (50 mg/kg) Mel was greatly elevated by the presence of Cya (at 50 mg/kg), which was able to induce a significant metabolic alteration to a level equivalent to that of 600 mg/kg Mel. Histological examination and serum biochemical analysis also indicated that the low-dose Mel-Cya mixture and high-dose Mel group resulted in the greatest renal toxicity. The high-dose Mel and low-dose Mel-Cya resulted in disrupted amino acid metabolism including tryptophan, polyamine, and tyrosine metabolism, and altered TCA and gut microflora structure. © 2010 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/342363 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.299 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xie, Guoxiang | - |
dc.contributor.author | Zheng, Xiaojiao | - |
dc.contributor.author | Qi, Xin | - |
dc.contributor.author | Cao, Yu | - |
dc.contributor.author | Chi, Yi | - |
dc.contributor.author | Su, Mingming | - |
dc.contributor.author | Ni, Yan | - |
dc.contributor.author | Qiu, Yunping | - |
dc.contributor.author | Liu, Yumin | - |
dc.contributor.author | Li, Houkai | - |
dc.contributor.author | Zhao, Aihua | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:03:16Z | - |
dc.date.available | 2024-04-17T07:03:16Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Proteome Research, 2010, v. 9, n. 1, p. 125-133 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342363 | - |
dc.description.abstract | The recent outbreak of renal failure in infants in China has been determined to be caused by melamine (Mel) and derivatives adulterated in the food. A metabonomic study was performed to evaluate the global biochemical alteration triggered by Mel ingestion in parallel with the acute renal toxicity in rats. Mel at 600, 300, and 100 mg/kg, cyanuric acid (Cya) at 100 mg/kg, and mixture of Mel and Cya (50 mg/kg each) were administered in five groups of Wistar rats, respectively, via oral gavage for 15 days. Urinary metabonomic profiles indicated that Mel perturbed urinary metabolism in a dose-dependent manner, with high-dose group showing the most significant impact. Metabonomic variations also suggest that the toxicity of low-dose (50 mg/kg) Mel was greatly elevated by the presence of Cya (at 50 mg/kg), which was able to induce a significant metabolic alteration to a level equivalent to that of 600 mg/kg Mel. Histological examination and serum biochemical analysis also indicated that the low-dose Mel-Cya mixture and high-dose Mel group resulted in the greatest renal toxicity. The high-dose Mel and low-dose Mel-Cya resulted in disrupted amino acid metabolism including tryptophan, polyamine, and tyrosine metabolism, and altered TCA and gut microflora structure. © 2010 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Proteome Research | - |
dc.subject | Cyanuric acid | - |
dc.subject | Melamine | - |
dc.subject | Metabonomics | - |
dc.subject | Multivariate statistical analysis | - |
dc.subject | Nephrotoxicity | - |
dc.subject | Ultraperformance liquid chromatography/ time-of-flight mass spectrometry | - |
dc.subject | Urine | - |
dc.title | Metabonomic evaluation of melamine-induced acute renal toxicity in rats | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/pr900333h | - |
dc.identifier.pmid | 19476335 | - |
dc.identifier.scopus | eid_2-s2.0-73649128909 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 125 | - |
dc.identifier.epage | 133 | - |
dc.identifier.isi | WOS:000273267900013 | - |