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Article: Metabonomics approach to understanding acute and chronic stress in rat models

TitleMetabonomics approach to understanding acute and chronic stress in rat models
Authors
KeywordsAcute stress
Chronic stress
Gas chromatography/mass spectrometry
Metabonomics
Multivariate analysis
Urine
Issue Date2009
Citation
Journal of Proteome Research, 2009, v. 8, n. 5, p. 2511-2518 How to Cite?
AbstractThe effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted in urine were analyzed using GC/MS in conjunction with multivariate and univariate statistical techniques. SD rats were subjected to two kinds of acute stress and chronic unpredictable mild stress, respectively. Metabolic analysis demonstrated that urinary expression of a number of metabolites including glutamate, glutamine, homovanillate, proline, succinate, citrate, and tyrosine altered in the acute stress model in the same way as in the chronic model, while pimelate and hippurate changed in the opposite trend. The results suggested that the stress induced metabolic perturbations were reversible and nonspecific. Metabolic response to chronic combined stress revealed biochemical clues to depression-like symptoms validated by behavior and physiologic results. This study provides a noninvasive and dynamic analytical strategy for the characterization of endogenous metabolic perturbations induced by external stress. © 2009 American Chemical Society. .
Persistent Identifierhttp://hdl.handle.net/10722/342355
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorZhao, Tie-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorSu, Mingming-
dc.contributor.authorJiang, Tao-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:11Z-
dc.date.available2024-04-17T07:03:11Z-
dc.date.issued2009-
dc.identifier.citationJournal of Proteome Research, 2009, v. 8, n. 5, p. 2511-2518-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342355-
dc.description.abstractThe effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted in urine were analyzed using GC/MS in conjunction with multivariate and univariate statistical techniques. SD rats were subjected to two kinds of acute stress and chronic unpredictable mild stress, respectively. Metabolic analysis demonstrated that urinary expression of a number of metabolites including glutamate, glutamine, homovanillate, proline, succinate, citrate, and tyrosine altered in the acute stress model in the same way as in the chronic model, while pimelate and hippurate changed in the opposite trend. The results suggested that the stress induced metabolic perturbations were reversible and nonspecific. Metabolic response to chronic combined stress revealed biochemical clues to depression-like symptoms validated by behavior and physiologic results. This study provides a noninvasive and dynamic analytical strategy for the characterization of endogenous metabolic perturbations induced by external stress. © 2009 American Chemical Society. .-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectAcute stress-
dc.subjectChronic stress-
dc.subjectGas chromatography/mass spectrometry-
dc.subjectMetabonomics-
dc.subjectMultivariate analysis-
dc.subjectUrine-
dc.titleMetabonomics approach to understanding acute and chronic stress in rat models-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr801086k-
dc.identifier.scopuseid_2-s2.0-66749153176-
dc.identifier.volume8-
dc.identifier.issue5-
dc.identifier.spage2511-
dc.identifier.epage2518-
dc.identifier.isiWOS:000265745300037-

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