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Article: Anti-inflammatory and anti-allergic effects of acidic fraction of Pheratima extract in asthma mice induced by ovalbumin

TitleAnti-inflammatory and anti-allergic effects of acidic fraction of Pheratima extract in asthma mice induced by ovalbumin
Authors
KeywordsAllergic asthma
Mice
Pheratima
Issue Date2008
Citation
Zhongguo Zhongyao Zazhi, 2008, v. 33, n. 19, p. 2249-2252 How to Cite?
AbstractObjective: To explore the effects of acidic fraction of Pheratima extract in an ovalbumin (OVA) induced asthma mouse model, and to provide the experimental evidences for the anti-asthmatic application of Pheratima extract with further purification and development. Method: Mice model of allergic asthma was established through the OVA challenge. To investigate the inflammatory cell level and Th1/Th2 levels as well as the therapeutic effects of acidic fraction from Pheratima extract, cell count of bronchoalveolar lavage fluid (BALF) was performed to evaluate the secretion of eosinophils (EOS) cells, and IgE, IL-4, IL-5, IL-13, IFN-γ levels were detected by ELISA. Result: Compared with control group, the EOS count of BALF in the model group was remarkably increased (P < 0.01), and IgE, IL-4, IL-5, IL-13 levels were also increased (P < 0.01), while IFN-γ decreased (P < 0.01). Acidic fraction from Pheratima (S) extract and its 30% ethanol washed fraction (S30) significantly inhibited the increase of EOS count (P < 0.01), decreased the IgE, IL-4, IL-5, IL-13 levels (P < 0.05), and inhibited the decrease of IFN-γ level (P < 0.01). Conclusion: The results indicate that inhibition of the EOS secretion and balancing of the altered Th1/Th2 levels may be important mechanisms of Pheratima's therapeutic effect in asthmatic mice model, and S30 is pharmacologically effective as evaluated with the above mentioned parameters, as a representative fraction of the Pheratima extract.
Persistent Identifierhttp://hdl.handle.net/10722/342338
ISSN
2023 SCImago Journal Rankings: 0.206

 

DC FieldValueLanguage
dc.contributor.authorZhou, Ming Mei-
dc.contributor.authorChu, Xiang Ping-
dc.contributor.authorYang, Hong Zhou-
dc.contributor.authorKou, Fang-
dc.contributor.authorZhao, Ai Hua-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:03:04Z-
dc.date.available2024-04-17T07:03:04Z-
dc.date.issued2008-
dc.identifier.citationZhongguo Zhongyao Zazhi, 2008, v. 33, n. 19, p. 2249-2252-
dc.identifier.issn1001-5302-
dc.identifier.urihttp://hdl.handle.net/10722/342338-
dc.description.abstractObjective: To explore the effects of acidic fraction of Pheratima extract in an ovalbumin (OVA) induced asthma mouse model, and to provide the experimental evidences for the anti-asthmatic application of Pheratima extract with further purification and development. Method: Mice model of allergic asthma was established through the OVA challenge. To investigate the inflammatory cell level and Th1/Th2 levels as well as the therapeutic effects of acidic fraction from Pheratima extract, cell count of bronchoalveolar lavage fluid (BALF) was performed to evaluate the secretion of eosinophils (EOS) cells, and IgE, IL-4, IL-5, IL-13, IFN-γ levels were detected by ELISA. Result: Compared with control group, the EOS count of BALF in the model group was remarkably increased (P < 0.01), and IgE, IL-4, IL-5, IL-13 levels were also increased (P < 0.01), while IFN-γ decreased (P < 0.01). Acidic fraction from Pheratima (S) extract and its 30% ethanol washed fraction (S30) significantly inhibited the increase of EOS count (P < 0.01), decreased the IgE, IL-4, IL-5, IL-13 levels (P < 0.05), and inhibited the decrease of IFN-γ level (P < 0.01). Conclusion: The results indicate that inhibition of the EOS secretion and balancing of the altered Th1/Th2 levels may be important mechanisms of Pheratima's therapeutic effect in asthmatic mice model, and S30 is pharmacologically effective as evaluated with the above mentioned parameters, as a representative fraction of the Pheratima extract.-
dc.languageeng-
dc.relation.ispartofZhongguo Zhongyao Zazhi-
dc.subjectAllergic asthma-
dc.subjectMice-
dc.subjectPheratima-
dc.titleAnti-inflammatory and anti-allergic effects of acidic fraction of Pheratima extract in asthma mice induced by ovalbumin-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19166019-
dc.identifier.scopuseid_2-s2.0-56749097907-
dc.identifier.volume33-
dc.identifier.issue19-
dc.identifier.spage2249-
dc.identifier.epage2252-

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