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- Publisher Website: 10.1038/nrd2505
- Scopus: eid_2-s2.0-38849190556
- PMID: 18239669
- WOS: WOS:000252806500011
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Article: Gut microbiota: A potential new territory for drug targeting
| Title | Gut microbiota: A potential new territory for drug targeting |
|---|---|
| Authors | |
| Issue Date | 2008 |
| Citation | Nature Reviews Drug Discovery, 2008, v. 7, n. 2, p. 123-129 How to Cite? |
| Abstract | The significant involvement of the gut microbiota in human health and disease suggests that manipulation of commensal microbial composition through combinations of antibiotics, probiotics and prebiotics could be a novel therapeutic approach. A systems perspective is needed to help understand the complex host-bacteria interactions and their association with pathophysiological phenotypes so that alterations in the composition of the gut microbiota in disease states can be reversed. In this article, we describe the therapeutic rationale and potential for targeting the gut microbiota, and discuss strategies and systems-oriented technologies for achieving this goal. |
| Persistent Identifier | http://hdl.handle.net/10722/342324 |
| ISSN | 2023 Impact Factor: 122.7 2023 SCImago Journal Rankings: 22.399 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jia, Wei | - |
| dc.contributor.author | Li, Houkai | - |
| dc.contributor.author | Zhao, Liping | - |
| dc.contributor.author | Nicholson, Jeremy K. | - |
| dc.date.accessioned | 2024-04-17T07:02:59Z | - |
| dc.date.available | 2024-04-17T07:02:59Z | - |
| dc.date.issued | 2008 | - |
| dc.identifier.citation | Nature Reviews Drug Discovery, 2008, v. 7, n. 2, p. 123-129 | - |
| dc.identifier.issn | 1474-1776 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/342324 | - |
| dc.description.abstract | The significant involvement of the gut microbiota in human health and disease suggests that manipulation of commensal microbial composition through combinations of antibiotics, probiotics and prebiotics could be a novel therapeutic approach. A systems perspective is needed to help understand the complex host-bacteria interactions and their association with pathophysiological phenotypes so that alterations in the composition of the gut microbiota in disease states can be reversed. In this article, we describe the therapeutic rationale and potential for targeting the gut microbiota, and discuss strategies and systems-oriented technologies for achieving this goal. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Nature Reviews Drug Discovery | - |
| dc.title | Gut microbiota: A potential new territory for drug targeting | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1038/nrd2505 | - |
| dc.identifier.pmid | 18239669 | - |
| dc.identifier.scopus | eid_2-s2.0-38849190556 | - |
| dc.identifier.volume | 7 | - |
| dc.identifier.issue | 2 | - |
| dc.identifier.spage | 123 | - |
| dc.identifier.epage | 129 | - |
| dc.identifier.eissn | 1474-1784 | - |
| dc.identifier.isi | WOS:000252806500011 | - |