File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Pharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats

TitlePharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats
Authors
KeywordsGC/MS
Intersubject difference
Metabolic phenotyping
Pharmacometabonomics
Predose metabolic profile
Xenobiotic intervention
Issue Date2007
Citation
Journal of Proteome Research, 2007, v. 6, n. 4, p. 1364-1370 How to Cite?
AbstractIn conventional pharmacological studies, intersubject differences within an animal strain are normally neglected, leading to variations in pharmacological outcomes in response to the same stimulus. Using two classical experimental models, the Streptozotocin (STZ)-induced diabetic model of Wistar rats and the high-energy, diet-induced obesity model of Sprague-Dawley rats, we demonstrate that the different outcomes of STZ or diet intervention are closely associated with variation in predose (baseline) urinary metabolic profiles of the rats. The pharmacometabonomic analysis of predose metabolic profiles indicates that the intersubject difference is, to a great extent, associated with gut-microbiota, which predisposes different pathophysiological outcomes upon diet alteration or chemical stimulus. We hypothesize that there may exist an important association between observations from these two models and the obese/diabetic human population in that subtle variations in metabolic phenotype may predetermine different systems' responses to xenobiotic perturbation, ultimately leading to varied pathophysiological processes. Results from two independent models also suggest that the pharmacometabonomics approach is of great importance in the study of pharmacology and clinical drug evaluations, where endogenous metabolite signatures of predose individuals should be taken into consideration to minimize intersubject difference and the resulting variation in the postdose pharmacological outcomes. © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342310
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Houkai-
dc.contributor.authorNi, Yan-
dc.contributor.authorSu, Mingming-
dc.contributor.authorQiu, Yunping-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorQiu, Mingfeng-
dc.contributor.authorZhao, Aihua-
dc.contributor.authorZhao, Liping-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:02:52Z-
dc.date.available2024-04-17T07:02:52Z-
dc.date.issued2007-
dc.identifier.citationJournal of Proteome Research, 2007, v. 6, n. 4, p. 1364-1370-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342310-
dc.description.abstractIn conventional pharmacological studies, intersubject differences within an animal strain are normally neglected, leading to variations in pharmacological outcomes in response to the same stimulus. Using two classical experimental models, the Streptozotocin (STZ)-induced diabetic model of Wistar rats and the high-energy, diet-induced obesity model of Sprague-Dawley rats, we demonstrate that the different outcomes of STZ or diet intervention are closely associated with variation in predose (baseline) urinary metabolic profiles of the rats. The pharmacometabonomic analysis of predose metabolic profiles indicates that the intersubject difference is, to a great extent, associated with gut-microbiota, which predisposes different pathophysiological outcomes upon diet alteration or chemical stimulus. We hypothesize that there may exist an important association between observations from these two models and the obese/diabetic human population in that subtle variations in metabolic phenotype may predetermine different systems' responses to xenobiotic perturbation, ultimately leading to varied pathophysiological processes. Results from two independent models also suggest that the pharmacometabonomics approach is of great importance in the study of pharmacology and clinical drug evaluations, where endogenous metabolite signatures of predose individuals should be taken into consideration to minimize intersubject difference and the resulting variation in the postdose pharmacological outcomes. © 2007 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectGC/MS-
dc.subjectIntersubject difference-
dc.subjectMetabolic phenotyping-
dc.subjectPharmacometabonomics-
dc.subjectPredose metabolic profile-
dc.subjectXenobiotic intervention-
dc.titlePharmacometabonomic phenotyping reveals different responses to xenobiotic intervention in rats-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr060513q-
dc.identifier.pmid17311441-
dc.identifier.scopuseid_2-s2.0-34248139693-
dc.identifier.volume6-
dc.identifier.issue4-
dc.identifier.spage1364-
dc.identifier.epage1370-
dc.identifier.isiWOS:000245510900013-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats