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Article: ZFP750 affects the cutaneous barrier through regulating lipid metabolism

TitleZFP750 affects the cutaneous barrier through regulating lipid metabolism
Authors
Issue Date2023
Citation
Science Advances, 2023, v. 9, n. 17, article no. eadg5423 How to Cite?
AbstractAn essential function of the epidermis is to provide a physical barrier that prevents the loss of water. Essential mediators of this barrier function include ceramides, cholesterol, and very long chain fatty acids, and their alteration causes human pathologies, including psoriasis and atopic dermatitis. A frameshift mutation in the human ZNF750 gene, which encodes a zinc finger transcription factor, has been shown to cause a seborrhea-like dermatitis. Here, we show that genetic deletion of the mouse homolog ZFP750 results in loss of epidermal barrier function, which is associated with a substantial reduction of ceramides, nonpolar lipids. The alteration of epidermal lipid homeostasis is directly linked to the transcriptional activity of ZFP750. ZFP750 directly and/or indirectly regulates the expression of crucial enzymes primarily involved in the biosynthesis of ceramides. Overall, our study identifies the transcription factor ZFP750 as a master regulator epidermal homeostasis through lipid biosynthesis and thus contributing to our understanding of the pathogenesis of several human skin diseases.
Persistent Identifierhttp://hdl.handle.net/10722/342269
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorButera, Alessio-
dc.contributor.authorAgostini, Massimiliano-
dc.contributor.authorCassandri, Matteo-
dc.contributor.authorDe Nicola, Francesca-
dc.contributor.authorFanciulli, Maurizio-
dc.contributor.authorD’Ambrosio, Lorenzo-
dc.contributor.authorFalasca, Laura-
dc.contributor.authorNardacci, Roberta-
dc.contributor.authorWang, Lu-
dc.contributor.authorPiacentini, Mauro-
dc.contributor.authorKnight, Richard A.-
dc.contributor.authorJia, Wei-
dc.contributor.authorSun, Qiang-
dc.contributor.authorShi, Yufang-
dc.contributor.authorWang, Ying-
dc.contributor.authorCandi, Eleonora-
dc.contributor.authorMelino, Gerry-
dc.date.accessioned2024-04-17T07:02:35Z-
dc.date.available2024-04-17T07:02:35Z-
dc.date.issued2023-
dc.identifier.citationScience Advances, 2023, v. 9, n. 17, article no. eadg5423-
dc.identifier.urihttp://hdl.handle.net/10722/342269-
dc.description.abstractAn essential function of the epidermis is to provide a physical barrier that prevents the loss of water. Essential mediators of this barrier function include ceramides, cholesterol, and very long chain fatty acids, and their alteration causes human pathologies, including psoriasis and atopic dermatitis. A frameshift mutation in the human ZNF750 gene, which encodes a zinc finger transcription factor, has been shown to cause a seborrhea-like dermatitis. Here, we show that genetic deletion of the mouse homolog ZFP750 results in loss of epidermal barrier function, which is associated with a substantial reduction of ceramides, nonpolar lipids. The alteration of epidermal lipid homeostasis is directly linked to the transcriptional activity of ZFP750. ZFP750 directly and/or indirectly regulates the expression of crucial enzymes primarily involved in the biosynthesis of ceramides. Overall, our study identifies the transcription factor ZFP750 as a master regulator epidermal homeostasis through lipid biosynthesis and thus contributing to our understanding of the pathogenesis of several human skin diseases.-
dc.languageeng-
dc.relation.ispartofScience Advances-
dc.titleZFP750 affects the cutaneous barrier through regulating lipid metabolism-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/SCIADV.ADG5423-
dc.identifier.pmid37115925-
dc.identifier.scopuseid_2-s2.0-85159243686-
dc.identifier.volume9-
dc.identifier.issue17-
dc.identifier.spagearticle no. eadg5423-
dc.identifier.epagearticle no. eadg5423-
dc.identifier.eissn2375-2548-
dc.identifier.isiWOS:000988217400003-

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