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Article: Early-life exposure to ambient air pollution with cardiovascular risk factors in adolescents: Findings from the “Children of 1997” Hong Kong birth cohort

TitleEarly-life exposure to ambient air pollution with cardiovascular risk factors in adolescents: Findings from the “Children of 1997” Hong Kong birth cohort
Authors
KeywordsAir pollution
Cardiovascular disease
Lipid profiles
Nitrogen oxides
PM10
Risk factors
Issue Date15-Apr-2024
PublisherElsevier
Citation
Science of the Total Environment, 2024, v. 921 How to Cite?
Abstract

Background: Long-term exposure to ambient air pollution is associated with cardiovascular disease (CVD) risk. Little is known about the impact of early-life exposure to air pollutants on CVD risk factors in late adolescence, which may track into adulthood. To clarify, we examined this question in a unique setting with high air pollution and a high level of economic development. Methods: This study leveraged the “Children of 1997” Hong Kong birth cohort (N = 8327), including here 3350 participants. We estimated ambient air pollutant exposure including inhalable particulate matter (PM), sulfur dioxide (SO), nitrogen dioxide (NO) and nitrogen monoxide (NO) by growth phase (in utero, infancy, childhood) and overall based on residential address. Generalized linear regression was used to assess the associations of air pollutants exposure by growth phase and sex with CVD risk factors (fasting blood glucose, glycosylated hemoglobin, lipid profile, blood pressure, and body mass index) at 17.6 years. We also assessed whether associations varied by sex. Results: Early life exposed had little association with glucose metabolism, blood pressure or body mass index, but after considering multiple comparisons early exposure to PM was associated with low density lipoprotein (LDL) in boys, with β and 95 % confidence intervals (95 % CI) of 0.184 (0.069 to 0.298) mmol/l, 0.151 (0.056 to 0.248) mmol/l, and 0.157 (0.063 to 0.252) mmol/l by per interquartile range (IQR) increment of PM for in utero, infancy, and overall, respectively. No such associations were evident for girls, differences by sex were evident. Conclusions: Our study suggested sex-specific associations of early-life PM exposure with elevated LDL in adolescence, especially exposure in utero and infancy.


Persistent Identifierhttp://hdl.handle.net/10722/342049
ISSN
2023 Impact Factor: 8.2
2023 SCImago Journal Rankings: 1.998
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShi, Wenming-
dc.contributor.authorSchooling, C Mary-
dc.contributor.authorLeung, Gabriel M-
dc.contributor.authorZhao, Jie V-
dc.date.accessioned2024-03-26T05:39:19Z-
dc.date.available2024-03-26T05:39:19Z-
dc.date.issued2024-04-15-
dc.identifier.citationScience of the Total Environment, 2024, v. 921-
dc.identifier.issn0048-9697-
dc.identifier.urihttp://hdl.handle.net/10722/342049-
dc.description.abstract<p>Background: Long-term exposure to ambient air pollution is associated with cardiovascular disease (CVD) risk. Little is known about the impact of early-life exposure to air pollutants on CVD risk factors in late adolescence, which may track into adulthood. To clarify, we examined this question in a unique setting with high air pollution and a high level of economic development. Methods: This study leveraged the “Children of 1997” Hong Kong birth cohort (N = 8327), including here 3350 participants. We estimated ambient air pollutant exposure including inhalable particulate matter (PM<inf/>), sulfur dioxide (SO<inf/>), nitrogen dioxide (NO<inf/>) and nitrogen monoxide (NO) by growth phase (in utero, infancy, childhood) and overall based on residential address. Generalized linear regression was used to assess the associations of air pollutants exposure by growth phase and sex with CVD risk factors (fasting blood glucose, glycosylated hemoglobin, lipid profile, blood pressure, and body mass index) at 17.6 years. We also assessed whether associations varied by sex. Results: Early life exposed had little association with glucose metabolism, blood pressure or body mass index, but after considering multiple comparisons early exposure to PM<inf/> was associated with low density lipoprotein (LDL) in boys, with β and 95 % confidence intervals (95 % CI) of 0.184 (0.069 to 0.298) mmol/l, 0.151 (0.056 to 0.248) mmol/l, and 0.157 (0.063 to 0.252) mmol/l by per interquartile range (IQR) increment of PM<inf/> for in utero, infancy, and overall, respectively. No such associations were evident for girls, differences by sex were evident. Conclusions: Our study suggested sex-specific associations of early-life PM<inf/> exposure with elevated LDL in adolescence, especially exposure in utero and infancy.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofScience of the Total Environment-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAir pollution-
dc.subjectCardiovascular disease-
dc.subjectLipid profiles-
dc.subjectNitrogen oxides-
dc.subjectPM10-
dc.subjectRisk factors-
dc.titleEarly-life exposure to ambient air pollution with cardiovascular risk factors in adolescents: Findings from the “Children of 1997” Hong Kong birth cohort-
dc.typeArticle-
dc.identifier.doi10.1016/j.scitotenv.2024.171119-
dc.identifier.scopuseid_2-s2.0-85185556250-
dc.identifier.volume921-
dc.identifier.eissn1879-1026-
dc.identifier.isiWOS:001204591900001-
dc.identifier.issnl0048-9697-

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