File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/s41443-024-00842-5
- Scopus: eid_2-s2.0-85186221623
- WOS: WOS:001178540600001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis
Title | Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis |
---|---|
Authors | |
Issue Date | 29-Feb-2024 |
Publisher | Springer Nature [academic journals on nature.com] |
Citation | International Journal of Impotence Research, 2024 How to Cite? |
Abstract | Penile cancer (PeCa) is rare, and the oncological outcomes in younger men are unclear. We aimed to analyse and compare oncological outcomes of men age ≤50 years (y) and >50 years with PeCa. A retrospective analysis of men ≤50 y with penile squamous cell carcinoma managed at a tertiary centre was performed. A propensity score matched cohort of men >50 y was identified for comparison. Matching was according to tumour, nodal stage and the types of primary surgery. Overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and metastasis-free survivals (MFS) were estimated using Kaplan–Meier plots and compared using log-rank tests. Between 2005–2020, 100 men ≤50 y (median (IQR) age, 46 y (40–49)) were identified and matched with 100 men >50 y (median (IQR) age, 65 y (59–73)). 10, 24, 32, 34 men age ≤50 y were diagnosed in 2005–2007, 2008–2012, 2013–2016 and 2017–2020 respectively. Median (IQR) follow-up was 53.5 (18–96) months. OS at 2 years: ≤50 y, 86%>50 y, 80.6%; 5 years: ≤50 y, 78.1%, >50 y, 63.1%; 10 years: ≤50 y, 72.3%, >50 y, 45.6% (p = 0.01). DSS at 2 years: ≤50 y, 87.2%>50 y, 87.8%; 5 years: ≤50 y, 80.9%>50 y, 78.2%; 10 years: ≤50 y, 78%, >50 y, 70.9% (p = 0.74). RFS was 93.1% in the ≤50 y group (vs. >50 y, 96.5%) at 2 year, and 90% (vs. >50 y, 88.5%) at 5 years, p = 0.81. Within the ≤50 y group, 2 years and 5 years MFS was 93% (vs. >50 y, 96.5%), and 89.5% (vs. >50 y, 92.7%) respectively, (p = 0.40). There were no statistical significance in DFS, RFS and MFS in men age ≤50 y and >50 y. PeCa in younger patients is fatal, public awareness and patient education are crucial for early detection and management. |
Persistent Identifier | http://hdl.handle.net/10722/341676 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.513 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pang, Karl H | - |
dc.contributor.author | Fallara, Giuseppe | - |
dc.contributor.author | Hemat, Morwarid | - |
dc.contributor.author | Ghosh, Akash | - |
dc.contributor.author | Haider, Aiman | - |
dc.contributor.author | Freeman, Alex | - |
dc.contributor.author | Hadway, Paul | - |
dc.contributor.author | Nigam, Raj | - |
dc.contributor.author | Rees, Rowland | - |
dc.contributor.author | Mitra, Anita | - |
dc.contributor.author | Alifrangis, Constantine | - |
dc.contributor.author | Muneer, Asif | - |
dc.contributor.author | Alnajjar, Hussain M | - |
dc.date.accessioned | 2024-03-20T06:58:12Z | - |
dc.date.available | 2024-03-20T06:58:12Z | - |
dc.date.issued | 2024-02-29 | - |
dc.identifier.citation | International Journal of Impotence Research, 2024 | - |
dc.identifier.issn | 0955-9930 | - |
dc.identifier.uri | http://hdl.handle.net/10722/341676 | - |
dc.description.abstract | <p>Penile cancer (PeCa) is rare, and the oncological outcomes in younger men are unclear. We aimed to analyse and compare oncological outcomes of men age ≤50 years (y) and >50 years with PeCa. A retrospective analysis of men ≤50 y with penile squamous cell carcinoma managed at a tertiary centre was performed. A propensity score matched cohort of men >50 y was identified for comparison. Matching was according to tumour, nodal stage and the types of primary surgery. Overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and metastasis-free survivals (MFS) were estimated using Kaplan–Meier plots and compared using log-rank tests. Between 2005–2020, 100 men ≤50 y (median (IQR) age, 46 y (40–49)) were identified and matched with 100 men >50 y (median (IQR) age, 65 y (59–73)). 10, 24, 32, 34 men age ≤50 y were diagnosed in 2005–2007, 2008–2012, 2013–2016 and 2017–2020 respectively. Median (IQR) follow-up was 53.5 (18–96) months. OS at 2 years: ≤50 y, 86%>50 y, 80.6%; 5 years: ≤50 y, 78.1%, >50 y, 63.1%; 10 years: ≤50 y, 72.3%, >50 y, 45.6% (<em>p</em> = 0.01). DSS at 2 years: ≤50 y, 87.2%>50 y, 87.8%; 5 years: ≤50 y, 80.9%>50 y, 78.2%; 10 years: ≤50 y, 78%, >50 y, 70.9% (<em>p</em> = 0.74). RFS was 93.1% in the ≤50 y group (vs. >50 y, 96.5%) at 2 year, and 90% (vs. >50 y, 88.5%) at 5 years, <em>p</em> = 0.81. Within the ≤50 y group, 2 years and 5 years MFS was 93% (vs. >50 y, 96.5%), and 89.5% (vs. >50 y, 92.7%) respectively, (<em>p</em> = 0.40). There were no statistical significance in DFS, RFS and MFS in men age ≤50 y and >50 y. PeCa in younger patients is fatal, public awareness and patient education are crucial for early detection and management.<br></p> | - |
dc.language | eng | - |
dc.publisher | Springer Nature [academic journals on nature.com] | - |
dc.relation.ispartof | International Journal of Impotence Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41443-024-00842-5 | - |
dc.identifier.scopus | eid_2-s2.0-85186221623 | - |
dc.identifier.eissn | 1476-5489 | - |
dc.identifier.isi | WOS:001178540600001 | - |
dc.identifier.issnl | 0955-9930 | - |