File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

TitleTumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
Authors
KeywordsCNA
ovarian cancer
radiomics
tertiary lymphoid structures
Issue Date2023
Citation
Cell Reports Medicine, 2023, v. 4, n. 7, article no. 101092 How to Cite?
AbstractTertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.
Persistent Identifierhttp://hdl.handle.net/10722/341411
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLu, Haonan-
dc.contributor.authorLou, Hantao-
dc.contributor.authorWengert, Georg-
dc.contributor.authorPaudel, Reema-
dc.contributor.authorPatel, Naina-
dc.contributor.authorDesai, Saral-
dc.contributor.authorCrum, Bill-
dc.contributor.authorLinton-Reid, Kristofer-
dc.contributor.authorChen, Mitchell-
dc.contributor.authorLi, Dongyang-
dc.contributor.authorIp, Jacey-
dc.contributor.authorMauri, Francesco-
dc.contributor.authorPinato, David J.-
dc.contributor.authorRockall, Andrea-
dc.contributor.authorCopley, Susan J.-
dc.contributor.authorGhaem-Maghami, Sadaf-
dc.contributor.authorAboagye, Eric O.-
dc.date.accessioned2024-03-13T08:42:37Z-
dc.date.available2024-03-13T08:42:37Z-
dc.date.issued2023-
dc.identifier.citationCell Reports Medicine, 2023, v. 4, n. 7, article no. 101092-
dc.identifier.urihttp://hdl.handle.net/10722/341411-
dc.description.abstractTertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.-
dc.languageeng-
dc.relation.ispartofCell Reports Medicine-
dc.subjectCNA-
dc.subjectovarian cancer-
dc.subjectradiomics-
dc.subjecttertiary lymphoid structures-
dc.titleTumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.xcrm.2023.101092-
dc.identifier.pmid37348499-
dc.identifier.scopuseid_2-s2.0-85165520991-
dc.identifier.volume4-
dc.identifier.issue7-
dc.identifier.spagearticle no. 101092-
dc.identifier.epagearticle no. 101092-
dc.identifier.eissn2666-3791-
dc.identifier.isiWOS:001048628700001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats