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- Publisher Website: 10.1021/jm4016137
- Scopus: eid_2-s2.0-84891283453
- WOS: WOS:000329331600025
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Article: Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions
Title | Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions |
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Authors | |
Issue Date | 2013 |
Citation | Journal of Medicinal Chemistry, 2013, v. 56, n. 24, p. 10171-10182 How to Cite? |
Abstract | In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions. © 2013 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/341148 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 1.986 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Benz, Sebastian | - |
dc.contributor.author | Nötzli, Sarah | - |
dc.contributor.author | Siegel, Jay S. | - |
dc.contributor.author | Eberli, Daniel | - |
dc.contributor.author | Jessen, Henning J. | - |
dc.date.accessioned | 2024-03-13T08:40:32Z | - |
dc.date.available | 2024-03-13T08:40:32Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Medicinal Chemistry, 2013, v. 56, n. 24, p. 10171-10182 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10722/341148 | - |
dc.description.abstract | In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions. © 2013 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Medicinal Chemistry | - |
dc.title | Controlled oxygen release from pyridone endoperoxides promotes cell survival under anoxic conditions | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/jm4016137 | - |
dc.identifier.scopus | eid_2-s2.0-84891283453 | - |
dc.identifier.volume | 56 | - |
dc.identifier.issue | 24 | - |
dc.identifier.spage | 10171 | - |
dc.identifier.epage | 10182 | - |
dc.identifier.eissn | 1520-4804 | - |
dc.identifier.isi | WOS:000329331600025 | - |