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Article: Genetic alphabetic order: What came before A?

TitleGenetic alphabetic order: What came before A?
Authors
Siegel, Jay S.Tor, Yitzhak
Issue Date2005
Citation
Organic and Biomolecular Chemistry, 2005, v. 3, n. 9, p. 1591-1592 How to Cite?
DOI: http://dx.doi.org/10.1039/b500921a
AbstractVarious theories regarding the incorporation of diaminopyrimidine 'D' as a nucleobase in DNA and RNA sequences are discussed. D could only participate in the code if it formed a glycoside through an exocyclic amino group. The thermodynamics benefit of complete pairing motivated a molecular mutation process that resulted in substitution of D. Independent of their possible role as precursor to the modern code, nucleosides formed through the exocyclic amines also offer an extension of the modern repertoire of nucleotide mimetics.
Persistent Identifierhttp://hdl.handle.net/10722/341069
ISSN
1477-0520
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.607
ISI Accession Number ID
WOS:000228719200014

 

DC FieldValueLanguage
dc.contributor.authorSiegel, Jay S.-
dc.contributor.authorTor, Yitzhak-
dc.date.accessioned2024-03-13T08:39:54Z-
dc.date.available2024-03-13T08:39:54Z-
dc.date.issued2005-
dc.identifier.citationOrganic and Biomolecular Chemistry, 2005, v. 3, n. 9, p. 1591-1592-
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10722/341069-
dc.description.abstractVarious theories regarding the incorporation of diaminopyrimidine 'D' as a nucleobase in DNA and RNA sequences are discussed. D could only participate in the code if it formed a glycoside through an exocyclic amino group. The thermodynamics benefit of complete pairing motivated a molecular mutation process that resulted in substitution of D. Independent of their possible role as precursor to the modern code, nucleosides formed through the exocyclic amines also offer an extension of the modern repertoire of nucleotide mimetics.-
dc.languageeng-
dc.relation.ispartofOrganic and Biomolecular Chemistry-
dc.titleGenetic alphabetic order: What came before A?-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b500921a-
dc.identifier.pmid15858634-
dc.identifier.scopuseid_2-s2.0-18844414848-
dc.identifier.volume3-
dc.identifier.issue9-
dc.identifier.spage1591-
dc.identifier.epage1592-
dc.identifier.isiWOS:000228719200014-

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