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Article: Exosomes as a modulator of immune resistance in human cancers

TitleExosomes as a modulator of immune resistance in human cancers
Authors
KeywordsCancer immunotherapy
Exosomes
Immune cells
Immune resistance
Tumor microenvironment
Issue Date24-Oct-2023
PublisherElsevier
Citation
Cytokine & Growth Factor Reviews, 2023, v. 73, p. 135-149 How to Cite?
Abstract

In the tumor microenvironment (TME), exosomes secreted by cells form interactive networks between the tumor cells and immune cells, thereby regulating immune signaling cascades in the TME. As key messengers of cell-to-cell communication in the TME, exosomes not only take charge of tumor cell antigen presentation to the immune cells, but also regulate the activities of immune cells, inhibit immune function, and, especially, promote immune resistance, all of which affects the therapeutic outcomes of tumors. Exosomes, which are small-sized vesicles, possess some remarkable advantages, including strong biological activity, a lack of immunogenicity and toxicity, and a strong targeting ability. Based on these characteristics, research on exosomes as biomarkers or carriers of tumor therapeutic drugs has become a research hotspot in related fields. This review describes the role of exosomes in cell communications in the TME, summarizes the effectiveness of exosome-based immunotherapy in overcoming immune resistance in cancer treatment, and systematically summarizes and discusses the characteristics of exosomes from different cell sources. Furthermore, the prospects and challenges of exosome-related therapies are discussed.


Persistent Identifierhttp://hdl.handle.net/10722/340979
ISSN
2023 Impact Factor: 9.3
2023 SCImago Journal Rankings: 2.460
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Lanzhou-
dc.contributor.authorWang, Chunyue-
dc.contributor.authorLi, Qiucheng-
dc.contributor.authorGuan, Yue-
dc.contributor.authorZhang, Xin-
dc.contributor.authorKong, Fange-
dc.contributor.authorFeng, Zixin-
dc.contributor.authorLu, Yuanjun-
dc.contributor.authorWang, Di-
dc.contributor.authorWang, Ning-
dc.date.accessioned2024-03-11T10:48:46Z-
dc.date.available2024-03-11T10:48:46Z-
dc.date.issued2023-10-24-
dc.identifier.citationCytokine & Growth Factor Reviews, 2023, v. 73, p. 135-149-
dc.identifier.issn1359-6101-
dc.identifier.urihttp://hdl.handle.net/10722/340979-
dc.description.abstract<p>In the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-microenvironment" title="Learn more about tumor microenvironment from ScienceDirect's AI-generated Topic Pages">tumor microenvironment</a> (TME), <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/exosome" title="Learn more about exosomes from ScienceDirect's AI-generated Topic Pages">exosomes</a> secreted by cells form interactive networks between the tumor cells and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunocompetent-cell" title="Learn more about immune cells from ScienceDirect's AI-generated Topic Pages">immune cells</a>, thereby regulating immune signaling cascades in the TME. As key messengers of cell-to-cell communication in the TME, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/exosome" title="Learn more about exosomes from ScienceDirect's AI-generated Topic Pages">exosomes</a> not only take charge of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-antigen" title="Learn more about tumor cell antigen from ScienceDirect's AI-generated Topic Pages">tumor cell antigen</a> presentation to the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunocompetent-cell" title="Learn more about immune cells from ScienceDirect's AI-generated Topic Pages">immune cells</a>, but also regulate the activities of immune cells, inhibit immune function, and, especially, promote immune resistance, all of which affects the therapeutic outcomes of tumors. Exosomes, which are small-sized vesicles, possess some remarkable advantages, including strong biological activity, a lack of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunogenicity" title="Learn more about immunogenicity from ScienceDirect's AI-generated Topic Pages">immunogenicity</a> and toxicity, and a strong targeting ability. Based on these characteristics, research on exosomes as biomarkers or carriers of tumor therapeutic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/chemotherapeutic-agent" title="Learn more about drugs from ScienceDirect's AI-generated Topic Pages">drugs</a> has become a research hotspot in related fields. This review describes the role of exosomes in cell communications in the TME, summarizes the effectiveness of exosome-based <a href="https://www.sciencedirect.com/topics/immunology-and-microbiology/immunotherapy" title="Learn more about immunotherapy from ScienceDirect's AI-generated Topic Pages">immunotherapy</a> in overcoming immune resistance in cancer treatment, and systematically summarizes and discusses the characteristics of exosomes from different cell sources. Furthermore, the prospects and challenges of exosome-related therapies are discussed.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofCytokine & Growth Factor Reviews-
dc.subjectCancer immunotherapy-
dc.subjectExosomes-
dc.subjectImmune cells-
dc.subjectImmune resistance-
dc.subjectTumor microenvironment-
dc.titleExosomes as a modulator of immune resistance in human cancers-
dc.typeArticle-
dc.identifier.doi10.1016/j.cytogfr.2023.07.007-
dc.identifier.scopuseid_2-s2.0-85167809511-
dc.identifier.volume73-
dc.identifier.spage135-
dc.identifier.epage149-
dc.identifier.eissn1879-0305-
dc.identifier.isiWOS:001088925900001-
dc.identifier.issnl1359-6101-

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