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- Publisher Website: 10.1093/jxb/erac203
- Scopus: eid_2-s2.0-85137394529
- WOS: WOS:000834322500001
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Article: Post-translational regulation of metabolic checkpoints in plant tetrapyrrole biosynthesis
Title | Post-translational regulation of metabolic checkpoints in plant tetrapyrrole biosynthesis |
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Authors | |
Keywords | Aminolevulinic acid chlorophyll chloroplast biogenesis metabolic control pigment synthesis post-translational control protein–protein interaction subcellular compartments tetrapyrrole biosynthesis |
Issue Date | 11-Aug-2022 |
Publisher | Oxford University Press |
Citation | Journal of Experimental Botany, 2022, v. 73, n. 14, p. 4624-4636 How to Cite? |
Abstract | The recently described regulatory factors and their functions at three main checkpoints of tetrapyrrole biosynthesis, which impact stability, enzymatic activity, and spatial organization of the committed enzymes of these three steps of the pathway, are reviewed. Tetrapyrrole biosynthesis produces metabolites that are essential for critical reactions in photosynthetic organisms, including chlorophylls, heme, siroheme, phytochromobilins, and their derivatives. Due to the paramount importance of tetrapyrroles, a better understanding of the complex regulation of tetrapyrrole biosynthesis promises to improve plant productivity in the context of global climate change. Tetrapyrrole biosynthesis is known to be controlled at multiple levels-transcriptional, translational and post-translational. This review addresses recent advances in our knowledge of the post-translational regulation of tetrapyrrole biosynthesis and summarizes the regulatory functions of the various auxiliary factors involved. Intriguingly, the post-translational network features three prominent metabolic checkpoints, located at the steps of (i) 5-aminolevulinic acid synthesis (the rate-limiting step in the pathway), (ii) the branchpoint between chlorophyll and heme synthesis, and (iii) the light-dependent enzyme protochlorophyllide oxidoreductase. The regulation of protein stability, enzymatic activity, and the spatial organization of the committed enzymes in these three steps ensures the appropriate flow of metabolites through the tetrapyrrole biosynthesis pathway during photoperiodic growth. In addition, we offer perspectives on currently open questions for future research on tetrapyrrole biosynthesis. |
Persistent Identifier | http://hdl.handle.net/10722/340953 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 1.739 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Peng | - |
dc.contributor.author | Ji, Shuiling | - |
dc.contributor.author | Grimm, Bernhard | - |
dc.date.accessioned | 2024-03-11T10:48:33Z | - |
dc.date.available | 2024-03-11T10:48:33Z | - |
dc.date.issued | 2022-08-11 | - |
dc.identifier.citation | Journal of Experimental Botany, 2022, v. 73, n. 14, p. 4624-4636 | - |
dc.identifier.issn | 0022-0957 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340953 | - |
dc.description.abstract | <p>The recently described regulatory factors and their functions at three main checkpoints of tetrapyrrole biosynthesis, which impact stability, enzymatic activity, and spatial organization of the committed enzymes of these three steps of the pathway, are reviewed.</p><p>Tetrapyrrole biosynthesis produces metabolites that are essential for critical reactions in photosynthetic organisms, including chlorophylls, heme, siroheme, phytochromobilins, and their derivatives. Due to the paramount importance of tetrapyrroles, a better understanding of the complex regulation of tetrapyrrole biosynthesis promises to improve plant productivity in the context of global climate change. Tetrapyrrole biosynthesis is known to be controlled at multiple levels-transcriptional, translational and post-translational. This review addresses recent advances in our knowledge of the post-translational regulation of tetrapyrrole biosynthesis and summarizes the regulatory functions of the various auxiliary factors involved. Intriguingly, the post-translational network features three prominent metabolic checkpoints, located at the steps of (i) 5-aminolevulinic acid synthesis (the rate-limiting step in the pathway), (ii) the branchpoint between chlorophyll and heme synthesis, and (iii) the light-dependent enzyme protochlorophyllide oxidoreductase. The regulation of protein stability, enzymatic activity, and the spatial organization of the committed enzymes in these three steps ensures the appropriate flow of metabolites through the tetrapyrrole biosynthesis pathway during photoperiodic growth. In addition, we offer perspectives on currently open questions for future research on tetrapyrrole biosynthesis.</p> | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Journal of Experimental Botany | - |
dc.subject | Aminolevulinic acid | - |
dc.subject | chlorophyll | - |
dc.subject | chloroplast biogenesis | - |
dc.subject | metabolic control | - |
dc.subject | pigment synthesis | - |
dc.subject | post-translational control | - |
dc.subject | protein–protein interaction | - |
dc.subject | subcellular compartments | - |
dc.subject | tetrapyrrole biosynthesis | - |
dc.title | Post-translational regulation of metabolic checkpoints in plant tetrapyrrole biosynthesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/jxb/erac203 | - |
dc.identifier.scopus | eid_2-s2.0-85137394529 | - |
dc.identifier.volume | 73 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | 4624 | - |
dc.identifier.epage | 4636 | - |
dc.identifier.eissn | 1460-2431 | - |
dc.identifier.isi | WOS:000834322500001 | - |
dc.identifier.issnl | 0022-0957 | - |