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Article: Targeting autophagy in ethnomedicine against human diseases
| Title | Targeting autophagy in ethnomedicine against human diseases |
|---|---|
| Authors | |
| Keywords | Autophagy Autophagy mechanisms Autophagy-related diseases Ethnomedicinal therapy Natural products |
| Issue Date | 1-Aug-2022 |
| Publisher | Elsevier |
| Citation | Journal of Ethnopharmacology, 2022, v. 282 How to Cite? |
| Abstract | Ethnopharmacological relevanceIn the past five years, ethnopharmacy-based drugs have been increasingly used in clinical practice. It has been reported that hundreds of ethnopharmacy-based drugs can modulate autophagy to regulate physiological and pathological processes, and ethnomedicines also have certain therapeutic effects on illnesses, revealing the important roles of these medicines in regulating autophagy and treating diseases. Aim of the studyThis study reviews the regulatory effects of natural products on autophagy in recent years, and discusses their pharmacological effects and clinical applications in the process of diseases. It provides a preliminary literature basis and reference for the research of plant drugs in the regulation of autophagy. Materials and methodsA comprehensive systematic review in the fields of relationship between autophagy and ethnomedicine in treating diseases from PubMed electronic database was performed. Information was obtained from documentary sources. ResultsWe recorded some illnesses associated with autophagy, then classified them into different categories reasonably. Based on the uses of these substances in different researches of diseases, a total of 80 active ingredients or compound preparations of natural drugs were searched. The autophagy mechanisms of these substances in the treatments of divers diseases have been summarized for the first time, we also looked forward to the clinical application of some of them. ConclusionsAutophagy plays a key function in lots of illnesses, the regulation of autophagy has become one of the important means to prevent and treat these diseases. About 80 compounds and preparations involved in this review have been proved to have therapeutic effects on related diseases through the mechanism of autophagy. Experiments in vivo and in vitro showed that these compounds and preparations could treat these diseases by regulating autophagy. The typical natural products curcumin and tripterine have powerful roles in regulating autophagy and show good and diversified curative effects. |
| Persistent Identifier | http://hdl.handle.net/10722/340796 |
| ISSN | 2021 Impact Factor: 5.195 2020 SCImago Journal Rankings: 0.885 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lai, Jia | - |
| dc.contributor.author | Tang, Yong | - |
| dc.contributor.author | Yang, Fei | - |
| dc.contributor.author | Chen, Jianping | - |
| dc.contributor.author | Huang, Fei-Hong | - |
| dc.contributor.author | Yang, Jing | - |
| dc.contributor.author | Wang, Long | - |
| dc.contributor.author | Qin, Dalian | - |
| dc.contributor.author | Law, Betty Yuen-Kwan | - |
| dc.contributor.author | Wu, An-Guo | - |
| dc.contributor.author | Wu, Jian-Ming | - |
| dc.date.accessioned | 2024-03-11T10:47:14Z | - |
| dc.date.available | 2024-03-11T10:47:14Z | - |
| dc.date.issued | 2022-08-01 | - |
| dc.identifier.citation | Journal of Ethnopharmacology, 2022, v. 282 | - |
| dc.identifier.issn | 0378-8741 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/340796 | - |
| dc.description.abstract | <h3>Ethnopharmacological relevance</h3><p>In the past five years, ethnopharmacy-based drugs have been increasingly used in clinical practice. It has been reported that hundreds of ethnopharmacy-based drugs can modulate autophagy to regulate physiological and pathological processes, and <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ethnomedicine" title="Learn more about ethnomedicines from ScienceDirect's AI-generated Topic Pages">ethnomedicines</a> also have certain therapeutic effects on illnesses, revealing the important roles of these medicines in regulating autophagy and treating diseases.</p><h3>Aim of the study</h3><p>This study reviews the regulatory effects of natural products on autophagy in recent years, and discusses their pharmacological effects and clinical applications in the process of diseases. It provides a preliminary literature basis and reference for the research of plant drugs in the regulation of autophagy.</p><h3>Materials and methods</h3><p>A comprehensive systematic review in the fields of relationship between autophagy and ethnomedicine in treating diseases from PubMed electronic database was performed. Information was obtained from documentary sources.</p><h3>Results</h3><p>We recorded some illnesses associated with autophagy, then classified them into different categories reasonably. Based on the uses of these substances in different researches of diseases, a total of 80 active ingredients or compound preparations of natural drugs were searched. The autophagy mechanisms of these substances in the treatments of <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/decompression-sickness" title="Learn more about divers diseases from ScienceDirect's AI-generated Topic Pages">divers diseases</a> have been summarized for the first time, we also looked forward to the clinical application of some of them.</p><h3>Conclusions</h3><p>Autophagy plays a key function in lots of illnesses, the regulation of autophagy has become one of the important means to prevent and treat these diseases. About 80 compounds and preparations involved in this review have been proved to have therapeutic effects on related diseases through the mechanism of autophagy. Experiments <em>in vivo</em> and <em>in vitro</em> showed that these compounds and preparations could treat these diseases by regulating autophagy. The typical natural products <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/curcumin" title="Learn more about curcumin from ScienceDirect's AI-generated Topic Pages">curcumin</a> and tripterine have powerful roles in regulating autophagy and show good and diversified curative effects.</p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Journal of Ethnopharmacology | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Autophagy | - |
| dc.subject | Autophagy mechanisms | - |
| dc.subject | Autophagy-related diseases | - |
| dc.subject | Ethnomedicinal therapy | - |
| dc.subject | Natural products | - |
| dc.title | Targeting autophagy in ethnomedicine against human diseases | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.jep.2021.114516 | - |
| dc.identifier.scopus | eid_2-s2.0-85115811066 | - |
| dc.identifier.hkuros | 341358 | - |
| dc.identifier.volume | 282 | - |
| dc.identifier.issnl | 0378-8741 | - |