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Article: ABO‐adjusted cPRA metric for kidney allocation in an Asian‐predominant population
Title | ABO‐adjusted cPRA metric for kidney allocation in an Asian‐predominant population |
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Authors | |
Keywords | ABO incompatibility cPRA HLA sensitization kidney transplantation organ allocation virtual crossmatch |
Issue Date | 1-Jan-2024 |
Publisher | Wiley |
Citation | HLA: Immune Response Genetics, 2024, v. 103, n. 1 How to Cite? |
Abstract | Recent studies showed that ABO-adjusted calculated panel reactive antibody (ABO-cPRA) may better reflect the histocompatibility level in a multi-ethnic population, but such data in Asians is not available. We developed an ABO-adjusted cPRA metric on a cohort of waitlist kidney transplant patients (n = 647, 99% Chinese) in Hong Kong, based on HLA alleles and ABO frequencies of local donors. The concordance between the web-based ABO-cPRA calculator and the impact on kidney allocation were evaluated. The blood group distribution for A, B, O and AB among waitlist kidney candidates were 26.2%, 27.5%, 40.1%, and 6.1%, and their chances of encountering incompatible blood group donors were 32.6%, 32.4%, 57.6%, and 0%, respectively. There is poor agreement between web-based ABO-cPRA calculator and our locally developed metrics. Over 90% of patients showed an increase in cPRA after ABO adjustment, most notably in those with cPRA between 70% and 79%. Blood group O patients had a much greater increase in cPRA scores after adjustment while patients of blood group A and B had similar increment. 10.6% of non-AB blood group waitlist patients had ABO-cPRA elevated to ≥80%. A local ABO-adjusted cPRA metric is required for Asian populations and may improve equity in kidney distribution for patients with disadvantageous blood groups. The result from the current study potentially helps other countries/localities in establishing their own unified ABO-cPRA metrics and predict the impact on kidney allocation. |
Persistent Identifier | http://hdl.handle.net/10722/340786 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 0.305 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lau, Kei Man | - |
dc.contributor.author | Chu, Patrick WK | - |
dc.contributor.author | Tang, Lydia WM | - |
dc.contributor.author | Chen, Bryan PY | - |
dc.contributor.author | Yeung, Nicholas KM | - |
dc.contributor.author | Ip, Patrick | - |
dc.contributor.author | Lee, Pamela | - |
dc.contributor.author | Yap, Desmond YH | - |
dc.contributor.author | Kwok, Janette SY | - |
dc.date.accessioned | 2024-03-11T10:47:06Z | - |
dc.date.available | 2024-03-11T10:47:06Z | - |
dc.date.issued | 2024-01-01 | - |
dc.identifier.citation | HLA: Immune Response Genetics, 2024, v. 103, n. 1 | - |
dc.identifier.issn | 2059-2302 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340786 | - |
dc.description.abstract | <p> <span>Recent studies showed that ABO-adjusted calculated panel reactive antibody (ABO-cPRA) may better reflect the histocompatibility level in a multi-ethnic population, but such data in Asians is not available. We developed an ABO-adjusted cPRA metric on a cohort of waitlist kidney transplant patients (n = 647, 99% Chinese) in Hong Kong, based on HLA alleles and ABO frequencies of local donors. The concordance between the web-based ABO-cPRA calculator and the impact on kidney allocation were evaluated. The blood group distribution for A, B, O and AB among waitlist kidney candidates were 26.2%, 27.5%, 40.1%, and 6.1%, and their chances of encountering incompatible blood group donors were 32.6%, 32.4%, 57.6%, and 0%, respectively. There is poor agreement between web-based ABO-cPRA calculator and our locally developed metrics. Over 90% of patients showed an increase in cPRA after ABO adjustment, most notably in those with cPRA between 70% and 79%. Blood group O patients had a much greater increase in cPRA scores after adjustment while patients of blood group A and B had similar increment. 10.6% of non-AB blood group waitlist patients had ABO-cPRA elevated to ≥80%. A local ABO-adjusted cPRA metric is required for Asian populations and may improve equity in kidney distribution for patients with disadvantageous blood groups. The result from the current study potentially helps other countries/localities in establishing their own unified ABO-cPRA metrics and predict the impact on kidney allocation.</span> <br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | HLA: Immune Response Genetics | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | ABO incompatibility | - |
dc.subject | cPRA | - |
dc.subject | HLA sensitization | - |
dc.subject | kidney transplantation | - |
dc.subject | organ allocation | - |
dc.subject | virtual crossmatch | - |
dc.title | ABO‐adjusted cPRA metric for kidney allocation in an Asian‐predominant population | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/tan.15229 | - |
dc.identifier.scopus | eid_2-s2.0-85171556403 | - |
dc.identifier.volume | 103 | - |
dc.identifier.issue | 1 | - |
dc.identifier.eissn | 2059-2310 | - |
dc.identifier.isi | WOS:001070325400001 | - |
dc.identifier.issnl | 2059-2302 | - |