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Article: Niuhuang Qingxin Pill ameliorates emotional behaviors through mediating neurogenesis and Trkb/ERK/CREB pathway in chronic restraint stress or corticosterone challenge mice.

TitleNiuhuang Qingxin Pill ameliorates emotional behaviors through mediating neurogenesis and Trkb/ERK/CREB pathway in chronic restraint stress or corticosterone challenge mice.
Authors
KeywordsBDNF/TrkB/ERK/CREB pathway
depression
hippocampal neurogenesis
neural stem cells
Niuhuang Qingxin Wan
Issue Date11-Jan-2024
PublisherFrontiers Media
Citation
Frontiers in Pharmacology, 2023, v. 14 How to Cite?
Abstract

Introduction: Chronic stress-associated hormonal imbalance impairs hippocampal neurogenesis, contributing to depressive and anxiety behaviors. Targeting neurogenesis is thus a promising antidepressant therapeutic strategy. Niuhuang Qingxin Wan (NHQXW) is an herbal formula for mental disorders in Traditional Chinese Medicine (TCM) practice, but its anti-depressant efficacies and mechanisms remain unverified.

Methods: In the present study, we tested the hypothesis that NHQXW could ameliorate depressive-like behaviors and improve hippocampal neurogenesis by modulating the TrkB/ERK/CREB signaling pathway by utilizing two depression mouse models including a chronic restraint stress (CRS) mouse model and a chronic corticosterone (CORT) stress (CCS) induced mouse model. The depression-like mouse models were orally treated with NHQXW whereas fluoxetine was used as the positive control group. We evaluated the effects of NHQXW on depressive- and anxiety-like behaviors and determined the effects of NHQXW on inducing hippocampal neurogenesis.

Results: NHQXW treatment significantly ameliorated depressive-like behaviors in those chronic stress mouse models. NHQXW significantly improved hippocampal neurogenesis in the CRS mice and CCS mice. The potential neurogenic mechanism of NHQXW was identified by regulating the expression levels of BDNF, TrkB, p-ERK (T202/T204), p-MEK1/2 (S217/221), and p-CREB (S133) in the hippocampus area of the CCS mice. NHQXW revealed its antidepressant and neurogenic effects that were similar to fluoxetine. Moreover, NHQXW treatment revealed long-term effects on preventing withdrawal-associated rebound symptoms in the CCS mice. Furthermore, in a bioactivity-guided quality control study, liquiritin was identified as one of the bioactive compounds of NHQXW with the bioactivities of neurogenesis-promoting effects.

Discussion: Taken together, NHQXW could be a promising TCM formula to attenuate depressive- and anxiety-like behaviors against chronic stress and depression. The underlying anti-depressant mechanisms could be correlated with its neurogenic activities by stimulating the TrkB/ERK/CREB signaling pathway.


Persistent Identifierhttp://hdl.handle.net/10722/340735
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.066
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDu, Q-
dc.contributor.authorGao, C-
dc.contributor.authorTsoi, B-
dc.contributor.authorWu, M-
dc.contributor.authorShen, J-
dc.date.accessioned2024-03-11T10:46:44Z-
dc.date.available2024-03-11T10:46:44Z-
dc.date.issued2024-01-11-
dc.identifier.citationFrontiers in Pharmacology, 2023, v. 14-
dc.identifier.issn1663-9812-
dc.identifier.urihttp://hdl.handle.net/10722/340735-
dc.description.abstract<p><strong>Introduction:</strong> Chronic stress-associated hormonal imbalance impairs hippocampal neurogenesis, contributing to depressive and anxiety behaviors. Targeting neurogenesis is thus a promising antidepressant therapeutic strategy. Niuhuang Qingxin Wan (NHQXW) is an herbal formula for mental disorders in Traditional Chinese Medicine (TCM) practice, but its anti-depressant efficacies and mechanisms remain unverified.</p><p><strong>Methods:</strong> In the present study, we tested the hypothesis that NHQXW could ameliorate depressive-like behaviors and improve hippocampal neurogenesis by modulating the TrkB/ERK/CREB signaling pathway by utilizing two depression mouse models including a chronic restraint stress (CRS) mouse model and a chronic corticosterone (CORT) stress (CCS) induced mouse model. The depression-like mouse models were orally treated with NHQXW whereas fluoxetine was used as the positive control group. We evaluated the effects of NHQXW on depressive- and anxiety-like behaviors and determined the effects of NHQXW on inducing hippocampal neurogenesis.</p><p><strong>Results:</strong> NHQXW treatment significantly ameliorated depressive-like behaviors in those chronic stress mouse models. NHQXW significantly improved hippocampal neurogenesis in the CRS mice and CCS mice. The potential neurogenic mechanism of NHQXW was identified by regulating the expression levels of BDNF, TrkB, p-ERK (T202/T204), p-MEK1/2 (S217/221), and p-CREB (S133) in the hippocampus area of the CCS mice. NHQXW revealed its antidepressant and neurogenic effects that were similar to fluoxetine. Moreover, NHQXW treatment revealed long-term effects on preventing withdrawal-associated rebound symptoms in the CCS mice. Furthermore, in a bioactivity-guided quality control study, liquiritin was identified as one of the bioactive compounds of NHQXW with the bioactivities of neurogenesis-promoting effects.</p><p><strong>Discussion:</strong> Taken together, NHQXW could be a promising TCM formula to attenuate depressive- and anxiety-like behaviors against chronic stress and depression. The underlying anti-depressant mechanisms could be correlated with its neurogenic activities by stimulating the TrkB/ERK/CREB signaling pathway.</p>-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Pharmacology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBDNF/TrkB/ERK/CREB pathway-
dc.subjectdepression-
dc.subjecthippocampal neurogenesis-
dc.subjectneural stem cells-
dc.subjectNiuhuang Qingxin Wan-
dc.titleNiuhuang Qingxin Pill ameliorates emotional behaviors through mediating neurogenesis and Trkb/ERK/CREB pathway in chronic restraint stress or corticosterone challenge mice.-
dc.typeArticle-
dc.identifier.doi10.3389/fphar.2023.1274343-
dc.identifier.scopuseid_2-s2.0-85183044225-
dc.identifier.volume14-
dc.identifier.eissn1663-9812-
dc.identifier.isiWOS:001148290800001-
dc.identifier.issnl1663-9812-

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