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- Publisher Website: 10.1016/j.apsb.2023.05.016
- Scopus: eid_2-s2.0-85163201042
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Article: Light-responsive nanomedicine for cancer immunotherapy
Title | Light-responsive nanomedicine for cancer immunotherapy |
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Authors | |
Keywords | Cancer therapy Immunotherapy Light-responsive nanoparticles Light-triggered drug release Nanomedicine Photodynamic therapy Photopharmacology Photothermal therapy |
Issue Date | 19-May-2023 |
Publisher | Elsevier |
Citation | Acta Pharmaceutica Sinica B, 2023, v. 13, n. 6, p. 2346-2368 How to Cite? |
Abstract | Immunotherapy emerged as a paradigm shift in cancer treatments, which can effectively inhibit cancer progression by activating the immune system. Remarkable clinical outcomes have been achieved through recent advances in cancer immunotherapy, including checkpoint blockades, adoptive cellular therapy, cancer vaccine, and tumor microenvironment modulation. However, extending the application of immunotherapy in cancer patients has been limited by the low response rate and side effects such as autoimmune toxicities. With great progress being made in nanotechnology, nanomedicine has been exploited to overcome biological barriers for drug delivery. Given the spatiotemporal control, light-responsive nanomedicine is of great interest in designing precise modality for cancer immunotherapy. Herein, we summarized current research utilizing light-responsive nanoplatforms to enhance checkpoint blockade immunotherapy, facilitate targeted delivery of cancer vaccines, activate immune cell functions, and modulate tumor microenvironment. The clinical translation potential of those designs is highlighted and challenges for the next breakthrough in cancer immunotherapy are discussed. |
Persistent Identifier | http://hdl.handle.net/10722/340563 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 3.035 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kang, Weirong | - |
dc.contributor.author | Liu, Yuwei | - |
dc.contributor.author | Wang, Weiping | - |
dc.date.accessioned | 2024-03-11T10:45:32Z | - |
dc.date.available | 2024-03-11T10:45:32Z | - |
dc.date.issued | 2023-05-19 | - |
dc.identifier.citation | Acta Pharmaceutica Sinica B, 2023, v. 13, n. 6, p. 2346-2368 | - |
dc.identifier.issn | 2211-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10722/340563 | - |
dc.description.abstract | <p>Immunotherapy emerged as a paradigm shift in cancer treatments, which can effectively inhibit cancer progression by activating the immune system. Remarkable clinical outcomes have been achieved through recent advances in cancer immunotherapy, including checkpoint blockades, adoptive cellular therapy, cancer vaccine, and tumor microenvironment modulation. However, extending the application of immunotherapy in cancer patients has been limited by the low response rate and side effects such as autoimmune toxicities. With great progress being made in nanotechnology, nanomedicine has been exploited to overcome biological barriers for drug delivery. Given the spatiotemporal control, light-responsive nanomedicine is of great interest in designing precise modality for cancer immunotherapy. Herein, we summarized current research utilizing light-responsive nanoplatforms to enhance checkpoint blockade immunotherapy, facilitate targeted delivery of cancer vaccines, activate immune cell functions, and modulate tumor microenvironment. The clinical translation potential of those designs is highlighted and challenges for the next breakthrough in cancer immunotherapy are discussed.<br></p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Acta Pharmaceutica Sinica B | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cancer therapy | - |
dc.subject | Immunotherapy | - |
dc.subject | Light-responsive nanoparticles | - |
dc.subject | Light-triggered drug release | - |
dc.subject | Nanomedicine | - |
dc.subject | Photodynamic therapy | - |
dc.subject | Photopharmacology | - |
dc.subject | Photothermal therapy | - |
dc.title | Light-responsive nanomedicine for cancer immunotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.apsb.2023.05.016 | - |
dc.identifier.scopus | eid_2-s2.0-85163201042 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 2346 | - |
dc.identifier.epage | 2368 | - |
dc.identifier.isi | WOS:001027052700001 | - |
dc.identifier.issnl | 2211-3835 | - |