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Article: Impact of comorbid allergic diseases on health-related quality of life of Hong Kong schoolchildren

TitleImpact of comorbid allergic diseases on health-related quality of life of Hong Kong schoolchildren
Authors
Keywordsallergic score
childhood allergic diseases
comorbid allergic diseases
health-related quality of life
ISAAC
schoolchildren
Issue Date1-May-2023
PublisherWiley
Citation
Pediatric Allergy and Immunology, 2023, v. 34, n. 5 How to Cite?
AbstractBackground: Studies on the relationship between childhood allergic disease and health-related quality of life (HRQOL) have mostly been confined to a single allergic condition. Therefore, a composite allergic score (CAS) was derived to assess the accumulated effect of eczema, asthma, and allergic rhinitis on HRQOL in Hong Kong schoolchildren. Methods: Parents of grade one/two or grade eight/nine schoolchildren completed a questionnaire assessing the prevalence and severity of eczema (POEM), asthma (C-ACT/ACT), and allergic rhinitis (VAS) and schoolchildren's HRQOL (PedsQL). Three rounds of recruitment were conducted. A total of 19 primary and 25 secondary schools agreed to participate. Results: Data from 1140 caregivers of grade one/two schoolchildren and 1048 grade eight/nine schoolchildren were imputed and analyzed. The proportion of female respondents were lower in grade one/two (37.7%) but higher in grade eight/nine (57.3%). 63.8% of grade one/two and 58.1% of grade eight/nine schoolchildren reported having at least one allergic disease. In general, greater disease severity was significantly associated with lower HRQOL. After controlling for age, gender, and allergic comorbidity in hierarchical regressions, CAS significantly predicted all HRQOL outcomes in both grade one/two and grade eight/nine schoolchildren. Female grade eight/nine schoolchildren reported lower HRQOL outcomes. Conclusion: Composite allergic score may be a practical tool to evaluate allergic comorbidity and the effectiveness of treatments targeting common pathological mechanisms of allergic diseases. Non-pharmaceutical approaches should be considered, especially for patients with more than one allergic disease and greater severity.
Persistent Identifierhttp://hdl.handle.net/10722/340534
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.050
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, CSY-
dc.contributor.authorChan, CHY-
dc.contributor.authorFung, YL-
dc.contributor.authorChau, PSY-
dc.contributor.authorLuk, DCK-
dc.contributor.authorCheng, JWCH-
dc.contributor.authorTsang, YP-
dc.contributor.authorLam, YY-
dc.contributor.authorChu, AKY-
dc.date.accessioned2024-03-11T10:45:19Z-
dc.date.available2024-03-11T10:45:19Z-
dc.date.issued2023-05-01-
dc.identifier.citationPediatric Allergy and Immunology, 2023, v. 34, n. 5-
dc.identifier.issn0905-6157-
dc.identifier.urihttp://hdl.handle.net/10722/340534-
dc.description.abstractBackground: Studies on the relationship between childhood allergic disease and health-related quality of life (HRQOL) have mostly been confined to a single allergic condition. Therefore, a composite allergic score (CAS) was derived to assess the accumulated effect of eczema, asthma, and allergic rhinitis on HRQOL in Hong Kong schoolchildren. Methods: Parents of grade one/two or grade eight/nine schoolchildren completed a questionnaire assessing the prevalence and severity of eczema (POEM), asthma (C-ACT/ACT), and allergic rhinitis (VAS) and schoolchildren's HRQOL (PedsQL). Three rounds of recruitment were conducted. A total of 19 primary and 25 secondary schools agreed to participate. Results: Data from 1140 caregivers of grade one/two schoolchildren and 1048 grade eight/nine schoolchildren were imputed and analyzed. The proportion of female respondents were lower in grade one/two (37.7%) but higher in grade eight/nine (57.3%). 63.8% of grade one/two and 58.1% of grade eight/nine schoolchildren reported having at least one allergic disease. In general, greater disease severity was significantly associated with lower HRQOL. After controlling for age, gender, and allergic comorbidity in hierarchical regressions, CAS significantly predicted all HRQOL outcomes in both grade one/two and grade eight/nine schoolchildren. Female grade eight/nine schoolchildren reported lower HRQOL outcomes. Conclusion: Composite allergic score may be a practical tool to evaluate allergic comorbidity and the effectiveness of treatments targeting common pathological mechanisms of allergic diseases. Non-pharmaceutical approaches should be considered, especially for patients with more than one allergic disease and greater severity.-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofPediatric Allergy and Immunology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectallergic score-
dc.subjectchildhood allergic diseases-
dc.subjectcomorbid allergic diseases-
dc.subjecthealth-related quality of life-
dc.subjectISAAC-
dc.subjectschoolchildren-
dc.titleImpact of comorbid allergic diseases on health-related quality of life of Hong Kong schoolchildren-
dc.typeArticle-
dc.identifier.doi10.1111/pai.13953-
dc.identifier.scopuseid_2-s2.0-85160430132-
dc.identifier.volume34-
dc.identifier.issue5-
dc.identifier.eissn1399-3038-
dc.identifier.isiWOS:000979921200001-
dc.identifier.issnl0905-6157-

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