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Article: Photonic double-network hydrogel dressings for antibacterial phototherapy and inflammation regulation in the general management of cutaneous regeneration

TitlePhotonic double-network hydrogel dressings for antibacterial phototherapy and inflammation regulation in the general management of cutaneous regeneration
Authors
Issue Date14-Jan-2023
PublisherRoyal Society of Chemistry
Citation
Nanoscale, 2023, v. 15, n. 2, p. 609-624 How to Cite?
Abstract

The treatment of festering pathogenic bacteria-induced skin wounds with increased inflammation is an ongoing challenge. The traditional antibacterial photothermal therapy always results in localized hyperthermia (over 50 °C), which inevitably delays tissue recovery. To address this serious issue, we devise a novel photonic hydrogel by integrating urchin-like Bi2S3 nano-heterojunctions (nano-HJs) into double-network hydrogels for infected skin regeneration. The synergy of NIR-triggered heat and ROS enables the hydrogels to achieve a rapid germicidal efficacy against bacteria within 15 min at mild temperature (below 50 °C). In vitro cell analysis results revealed that the photonic hydrogels exhibit superior cytocompatibility even after NIR illumination. More importantly, an in vivo study demonstrated that the photonic hydrogel dressings have a robust ability of accelerating contagious full-thickness wound regeneration through debriding abscesses, eliminating pathogens, improving collagen deposition, promoting angiogenesis, and adjusting the inflammation state. This photonic hydrogel system provides a general management strategy for the remedy of infectious wounds, where the incorporation of nano-HJs endows the hydrogels with the photodisinfection ability; in addition, the multifunctional hydrogels alleviate the damage from overwhelming heat towards surrounding tissues during phototherapy and steer the inflammation during the process of tissue regeneration. Accordingly, this work highlights the promising application of the photonic hydrogels in conquering refractory pathogen-invaded infection.


Persistent Identifierhttp://hdl.handle.net/10722/340231
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 1.416
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, Jiyu-
dc.contributor.authorDeng, Yi-
dc.contributor.authorHan, Qiuyang-
dc.contributor.authorMa, Daichuan-
dc.contributor.authorChan, Yau Kei-
dc.contributor.authorHe, Shuai-
dc.contributor.authorZhou, Xiong-
dc.contributor.authorWang, Hao-
dc.contributor.authorFu, Xinliang-
dc.contributor.authorGan, Xueqi-
dc.date.accessioned2024-03-11T10:42:39Z-
dc.date.available2024-03-11T10:42:39Z-
dc.date.issued2023-01-14-
dc.identifier.citationNanoscale, 2023, v. 15, n. 2, p. 609-624-
dc.identifier.issn2040-3364-
dc.identifier.urihttp://hdl.handle.net/10722/340231-
dc.description.abstract<p>The treatment of festering pathogenic bacteria-induced skin wounds with increased inflammation is an ongoing challenge. The traditional antibacterial photothermal therapy always results in localized hyperthermia (over 50 °C), which inevitably delays tissue recovery. To address this serious issue, we devise a novel photonic hydrogel by integrating urchin-like Bi<small><sub>2</sub></small>S<small><sub>3</sub></small> nano-heterojunctions (nano-HJs) into double-network hydrogels for infected skin regeneration. The synergy of NIR-triggered heat and ROS enables the hydrogels to achieve a rapid germicidal efficacy against bacteria within 15 min at mild temperature (below 50 °C). <em>In vitro</em> cell analysis results revealed that the photonic hydrogels exhibit superior cytocompatibility even after NIR illumination. More importantly, an <em>in vivo</em> study demonstrated that the photonic hydrogel dressings have a robust ability of accelerating contagious full-thickness wound regeneration through debriding abscesses, eliminating pathogens, improving collagen deposition, promoting angiogenesis, and adjusting the inflammation state. This photonic hydrogel system provides a general management strategy for the remedy of infectious wounds, where the incorporation of nano-HJs endows the hydrogels with the photodisinfection ability; in addition, the multifunctional hydrogels alleviate the damage from overwhelming heat towards surrounding tissues during phototherapy and steer the inflammation during the process of tissue regeneration. Accordingly, this work highlights the promising application of the photonic hydrogels in conquering refractory pathogen-invaded infection.<br></p>-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.ispartofNanoscale-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePhotonic double-network hydrogel dressings for antibacterial phototherapy and inflammation regulation in the general management of cutaneous regeneration-
dc.typeArticle-
dc.identifier.doi10.1039/d2nr03267h-
dc.identifier.scopuseid_2-s2.0-85144641161-
dc.identifier.volume15-
dc.identifier.issue2-
dc.identifier.spage609-
dc.identifier.epage624-
dc.identifier.eissn2040-3372-
dc.identifier.isiWOS:000897615800001-
dc.identifier.issnl2040-3364-

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