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Article: Causal Effects of Modifiable Behaviors on Prostate Cancer in Europeans and East Asians: A Comprehensive Mendelian Randomization Study

TitleCausal Effects of Modifiable Behaviors on Prostate Cancer in Europeans and East Asians: A Comprehensive Mendelian Randomization Study
Authors
Keywordscausality
mendelian randomization
modifiable lifestyle behavior
prostate cancer
Issue Date29-Apr-2023
PublisherMDPI
Citation
Biology, 2023, v. 12, n. 5 How to Cite?
Abstract

Objective: Early evidence is disputable for the effects of modifiable lifestyle behaviors on prostate cancer (PCa) risk. No research has yet appraised such causality in different ancestries using a Mendelian randomization (MR) approach. Methods: A two-sample univariable and multivariable MR analysis was performed. Genetic instruments associated with lifestyle behaviors were selected based on genome-wide association studies. Summary-level data for PCa were obtained from PRACTICAL and GAME-ON/ELLIPSE consortia for Europeans (79,148 PCa cases and 61,106 controls), and ChinaPCa consortium for East Asians (3343 cases and 3315 controls). Replication was performed using FinnGen (6311 cases and 88,902 controls) and BioBank Japan data (5408 cases and 103,939 controls). Results: Tobacco smoking was identified as increasing PCa risks in Europeans (odds ratio [OR]: 1.95, 95% confidence interval [CI]: 1.09–3.50, p = 0.027 per standard deviation increase in the lifetime smoking index). For East Asians, alcohol drinking (OR: 1.05, 95%CI: 1.01–1.09, p = 0.011) and delayed sexual initiation (OR: 1.04, 95%CI: 1.00–1.08, p = 0.029) were identified as risk factors, while cooked vegetable consumption (OR: 0.92, 95%CI: 0.88–0.96, p = 0.001) was a protective factor for PCa. Conclusions: Our findings broaden the evidence base for the spectrum of PCa risk factors in different ethnicities, and provide insights into behavioral interventions for prostate cancer.


Persistent Identifierhttp://hdl.handle.net/10722/340197
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 0.815
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhan, YL-
dc.contributor.authorRuan, XH-
dc.contributor.authorWang, P-
dc.contributor.authorHuang, D-
dc.contributor.authorHuang, JY-
dc.contributor.authorHuang, JL-
dc.contributor.authorChun, TTS-
dc.contributor.authorHo, BSH-
dc.contributor.authorNg, ATL-
dc.contributor.authorTsu, JHL-
dc.contributor.authorNa, R-
dc.date.accessioned2024-03-11T10:42:24Z-
dc.date.available2024-03-11T10:42:24Z-
dc.date.issued2023-04-29-
dc.identifier.citationBiology, 2023, v. 12, n. 5-
dc.identifier.issn2079-7737-
dc.identifier.urihttp://hdl.handle.net/10722/340197-
dc.description.abstract<p>Objective: Early evidence is disputable for the effects of modifiable lifestyle behaviors on prostate cancer (PCa) risk. No research has yet appraised such causality in different ancestries using a Mendelian randomization (MR) approach. Methods: A two-sample univariable and multivariable MR analysis was performed. Genetic instruments associated with lifestyle behaviors were selected based on genome-wide association studies. Summary-level data for PCa were obtained from PRACTICAL and GAME-ON/ELLIPSE consortia for Europeans (79,148 PCa cases and 61,106 controls), and ChinaPCa consortium for East Asians (3343 cases and 3315 controls). Replication was performed using FinnGen (6311 cases and 88,902 controls) and BioBank Japan data (5408 cases and 103,939 controls). Results: Tobacco smoking was identified as increasing PCa risks in Europeans (odds ratio [OR]: 1.95, 95% confidence interval [CI]: 1.09–3.50, p = 0.027 per standard deviation increase in the lifetime smoking index). For East Asians, alcohol drinking (OR: 1.05, 95%CI: 1.01–1.09, p = 0.011) and delayed sexual initiation (OR: 1.04, 95%CI: 1.00–1.08, p = 0.029) were identified as risk factors, while cooked vegetable consumption (OR: 0.92, 95%CI: 0.88–0.96, p = 0.001) was a protective factor for PCa. Conclusions: Our findings broaden the evidence base for the spectrum of PCa risk factors in different ethnicities, and provide insights into behavioral interventions for prostate cancer.</p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofBiology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcausality-
dc.subjectmendelian randomization-
dc.subjectmodifiable lifestyle behavior-
dc.subjectprostate cancer-
dc.titleCausal Effects of Modifiable Behaviors on Prostate Cancer in Europeans and East Asians: A Comprehensive Mendelian Randomization Study-
dc.typeArticle-
dc.identifier.doi10.3390/biology12050673-
dc.identifier.scopuseid_2-s2.0-85160357679-
dc.identifier.volume12-
dc.identifier.issue5-
dc.identifier.eissn2079-7737-
dc.identifier.isiWOS:000995607600001-
dc.identifier.issnl2079-7737-

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