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Article: Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants

TitleControlled release and biocompatibility of polymer/titania nanotube array system on titanium implants
Authors
KeywordsAntibacterial
Biocompatibility
Coating
Drug delivery
Implants
Issue Date10-Feb-2017
PublisherElsevier
Citation
Bioactive Materials, 2017, v. 2, n. 1, p. 44-50 How to Cite?
AbstractBacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants; thus, surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic implants. In this work, a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid) (PLGA) and titania nanotubes (TNTs) has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug release. By varying the size of the TNTs and the thickness of the polymer film, the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment time. The size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid coatings. In this work, TNTs with an average size of 80 nm can achieve the largest loading dose. Depending on the polymer thickness, significant improvement in the drug release characteristics is attained, for instance, reduced burst release (from 84% to 27%) and overall release time extended from 5 to over 40 days. In addition, the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier stage. Therefore, this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials.
Persistent Identifierhttp://hdl.handle.net/10722/340181
ISSN
2023 Impact Factor: 18.0
2023 SCImago Journal Rankings: 3.466
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, TT-
dc.contributor.authorWeng, ZY-
dc.contributor.authorLiu, XM-
dc.contributor.authorYeung, KWK-
dc.contributor.authorPan, HB-
dc.contributor.authorWu, SL -
dc.date.accessioned2024-03-11T10:42:16Z-
dc.date.available2024-03-11T10:42:16Z-
dc.date.issued2017-02-10-
dc.identifier.citationBioactive Materials, 2017, v. 2, n. 1, p. 44-50-
dc.identifier.issn2452-199X-
dc.identifier.urihttp://hdl.handle.net/10722/340181-
dc.description.abstractBacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants; thus, surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic implants. In this work, a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid) (PLGA) and titania nanotubes (TNTs) has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug release. By varying the size of the TNTs and the thickness of the polymer film, the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment time. The size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid coatings. In this work, TNTs with an average size of 80 nm can achieve the largest loading dose. Depending on the polymer thickness, significant improvement in the drug release characteristics is attained, for instance, reduced burst release (from 84% to 27%) and overall release time extended from 5 to over 40 days. In addition, the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier stage. Therefore, this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofBioactive Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntibacterial-
dc.subjectBiocompatibility-
dc.subjectCoating-
dc.subjectDrug delivery-
dc.subjectImplants-
dc.titleControlled release and biocompatibility of polymer/titania nanotube array system on titanium implants-
dc.typeArticle-
dc.identifier.doi10.1016/j.bioactmat.2017.02.001-
dc.identifier.scopuseid_2-s2.0-85040043950-
dc.identifier.volume2-
dc.identifier.issue1-
dc.identifier.spage44-
dc.identifier.epage50-
dc.identifier.eissn2452-199X-
dc.identifier.isiWOS:000446882300006-
dc.identifier.issnl2452-199X-

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