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Article: A comparison of cardiovascular disease, cancer, mortality, and Graves' ophthalmopathy following treatment for hyperthyroidism: A Bayesian network meta‐analysis
Title | A comparison of cardiovascular disease, cancer, mortality, and Graves' ophthalmopathy following treatment for hyperthyroidism: A Bayesian network meta‐analysis |
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Authors | |
Issue Date | 18-Jan-2024 |
Publisher | Wiley |
Citation | World Journal of Surgery, 2024, p. 1-15 How to Cite? |
Abstract | ObjectivesThis network meta-analysis aimed to evaluate the association of anti-thyroid drugs (ATD), radioactive iodine (RAI), and thyroidectomy with subsequent outcomes in patients with newly-diagnosed hyperthyroidism. MethodsThe Ovid Medline, Ovid Embase, and Cochrane Library databases were searched for observational studies and randomized controlled trials. Included studies were published on or before 1st May 2022 involving at least two of the treatments among ATD, RAI, and thyroidectomy for hyperthyroidism. Pairwise comparisons and Bayesian network meta-analysis were used to estimate hazard ratios (HRs) and their credible interval (CrI) of outcomes, including cardiovascular disease (CVD), cancer, overall mortality, and Graves' ophthalmopathy (GO). ResultsA total of 22 cohort studies with 131,297 hyperthyroidism patients were included. Thyroidectomy was associated with lower risks of mortality and GO than ATD (HR = 0.54, 95% CrI: 0.31, 0.96; HR = 0.31, 95% CrI: 0.12, 0.64) and RAI (HR = 0.62, 95% CrI: 0.41, 0.95; HR = 0.18, 95% CrI: 0.07, 0.35). RAI had a higher risk of GO (HR = 1.70, 95% CrI: 1.02, 2.99) than ATD treatment. ConclusionsThis Bayesian network meta-analysis indicated that thyroidectomy was associated with lower risks of mortality and GO in newly-diagnosed hyperthyroid patients compared to ATD and RAI. Relative to ATD, RAI therapy increased the risk of GO. |
Persistent Identifier | http://hdl.handle.net/10722/339889 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.772 |
DC Field | Value | Language |
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dc.contributor.author | Liu, Xiaodong | - |
dc.contributor.author | Wong, Carlos K H | - |
dc.contributor.author | Wu, Tingting | - |
dc.contributor.author | Chan, Wendy W L | - |
dc.contributor.author | Woo, Yu Cho | - |
dc.contributor.author | Lam, Cindy L K | - |
dc.contributor.author | Lang, Brian H H | - |
dc.date.accessioned | 2024-03-11T10:40:03Z | - |
dc.date.available | 2024-03-11T10:40:03Z | - |
dc.date.issued | 2024-01-18 | - |
dc.identifier.citation | World Journal of Surgery, 2024, p. 1-15 | - |
dc.identifier.issn | 0364-2313 | - |
dc.identifier.uri | http://hdl.handle.net/10722/339889 | - |
dc.description.abstract | <h3>Objectives</h3><p>This network meta-analysis aimed to evaluate the association of anti-thyroid drugs (ATD), radioactive iodine (RAI), and thyroidectomy with subsequent outcomes in patients with newly-diagnosed hyperthyroidism.</p><h3>Methods</h3><p>The Ovid Medline, Ovid Embase, and Cochrane Library databases were searched for observational studies and randomized controlled trials. Included studies were published on or before 1st May 2022 involving at least two of the treatments among ATD, RAI, and thyroidectomy for hyperthyroidism. Pairwise comparisons and Bayesian network meta-analysis were used to estimate hazard ratios (HRs) and their credible interval (CrI) of outcomes, including cardiovascular disease (CVD), cancer, overall mortality, and Graves' ophthalmopathy (GO).</p><h3>Results</h3><p>A total of 22 cohort studies with 131,297 hyperthyroidism patients were included. Thyroidectomy was associated with lower risks of mortality and GO than ATD (HR = 0.54, 95% CrI: 0.31, 0.96; HR = 0.31, 95% CrI: 0.12, 0.64) and RAI (HR = 0.62, 95% CrI: 0.41, 0.95; HR = 0.18, 95% CrI: 0.07, 0.35). RAI had a higher risk of GO (HR = 1.70, 95% CrI: 1.02, 2.99) than ATD treatment.</p><h3>Conclusions</h3><p>This Bayesian network meta-analysis indicated that thyroidectomy was associated with lower risks of mortality and GO in newly-diagnosed hyperthyroid patients compared to ATD and RAI. Relative to ATD, RAI therapy increased the risk of GO.</p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | World Journal of Surgery | - |
dc.title | A comparison of cardiovascular disease, cancer, mortality, and Graves' ophthalmopathy following treatment for hyperthyroidism: A Bayesian network meta‐analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/wjs.12066 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 15 | - |
dc.identifier.eissn | 1432-2323 | - |
dc.identifier.issnl | 0364-2313 | - |