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Article: Multi-route transmission potential of SARS-CoV-2 in healthcare facilities

TitleMulti-route transmission potential of SARS-CoV-2 in healthcare facilities
Authors
KeywordsAerosol
COVID-19
Environmental sampling
Exhaled breath
SARS-CoV-2
Issue Date15-Jan-2021
PublisherElsevier
Citation
Journal of Hazardous Materials, 2021, v. 402 How to Cite?
AbstractUnderstanding the transmission mechanism of SARS-CoV-2 is a prerequisite to effective control measures. To investigate the potential modes of SARS-CoV-2 transmission, 21 COVID-19 patients from 12-47 days after symptom onset were recruited. We monitored the release of SARS-CoV-2 from the patients' exhaled breath and systematically investigated environmental contamination of air, public surfaces, personal necessities, and the drainage system. SARS-CoV-2 RNA was detected in 0 of 9 exhaled breath samples, 2 of 8 exhaled breath condensate samples, 1 of 12 bedside air samples, 4 of 132 samples from private surfaces, 0 of 70 samples from frequently touched public surfaces in isolation rooms, and 7 of 23 feces-related air/surface/water samples. The maximum viral RNA concentrations were 1857 copies/m3 in the air, 38 copies/cm2 in sampled surfaces and 3092 copies/mL in sewage/wastewater samples. Our results suggest that nosocomial transmission of SARS-CoV-2 can occur via multiple routes. However, the low detection frequency and limited quantity of viral RNA from the breath and environmental specimens may be related to the reduced viral load of the COVID-19 patients on later days after symptom onset. These findings suggest that the transmission dynamics of SARS-CoV-2 differ from those of SARS-CoV in healthcare settings.
Persistent Identifierhttp://hdl.handle.net/10722/339831
ISSN
2023 Impact Factor: 12.2
2023 SCImago Journal Rankings: 2.950
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeng, BH-
dc.contributor.authorXu, KJ-
dc.contributor.authorGu, SL-
dc.contributor.authorZheng, SF-
dc.contributor.authorZou, QD-
dc.contributor.authorXu, Y-
dc.contributor.authorYu, L-
dc.contributor.authorLou, FY-
dc.contributor.authorYu, F-
dc.contributor.authorJin, T-
dc.contributor.authorLi, YG-
dc.contributor.authorSheng, JF-
dc.contributor.authorYen, HL-
dc.contributor.authorZhong, ZF-
dc.contributor.authorWei, JJ-
dc.contributor.authorChen, Y-
dc.date.accessioned2024-03-11T10:39:37Z-
dc.date.available2024-03-11T10:39:37Z-
dc.date.issued2021-01-15-
dc.identifier.citationJournal of Hazardous Materials, 2021, v. 402-
dc.identifier.issn0304-3894-
dc.identifier.urihttp://hdl.handle.net/10722/339831-
dc.description.abstractUnderstanding the transmission mechanism of SARS-CoV-2 is a prerequisite to effective control measures. To investigate the potential modes of SARS-CoV-2 transmission, 21 COVID-19 patients from 12-47 days after symptom onset were recruited. We monitored the release of SARS-CoV-2 from the patients' exhaled breath and systematically investigated environmental contamination of air, public surfaces, personal necessities, and the drainage system. SARS-CoV-2 RNA was detected in 0 of 9 exhaled breath samples, 2 of 8 exhaled breath condensate samples, 1 of 12 bedside air samples, 4 of 132 samples from private surfaces, 0 of 70 samples from frequently touched public surfaces in isolation rooms, and 7 of 23 feces-related air/surface/water samples. The maximum viral RNA concentrations were 1857 copies/m3 in the air, 38 copies/cm2 in sampled surfaces and 3092 copies/mL in sewage/wastewater samples. Our results suggest that nosocomial transmission of SARS-CoV-2 can occur via multiple routes. However, the low detection frequency and limited quantity of viral RNA from the breath and environmental specimens may be related to the reduced viral load of the COVID-19 patients on later days after symptom onset. These findings suggest that the transmission dynamics of SARS-CoV-2 differ from those of SARS-CoV in healthcare settings.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofJournal of Hazardous Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAerosol-
dc.subjectCOVID-19-
dc.subjectEnvironmental sampling-
dc.subjectExhaled breath-
dc.subjectSARS-CoV-2-
dc.titleMulti-route transmission potential of SARS-CoV-2 in healthcare facilities-
dc.typeArticle-
dc.identifier.doi10.1016/j.jhazmat.2020.123771-
dc.identifier.pmid33254782-
dc.identifier.scopuseid_2-s2.0-85089898432-
dc.identifier.volume402-
dc.identifier.eissn1873-3336-
dc.identifier.isiWOS:000593839500007-
dc.publisher.placeAMSTERDAM-
dc.identifier.issnl0304-3894-

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