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Article: Range adaptive value representations in schizophrenia and major depression

TitleRange adaptive value representations in schizophrenia and major depression
Authors
Issue Date1-Feb-2024
PublisherElsevier
Citation
Asian Journal of Psychiatry, 2024, v. 92 How to Cite?
Abstract

Anhedonia and amotivation are core symptoms of schizophrenia (SCZ) and major depressive disorder (MDD). Reward processing involves constructing and contrasting the representations for expected value (EV) and outcome value (OV) of a given stimulus, a phenomenon termed range adaptation. Impaired range adaptation can lead to anhedonia and amotivation. This study aimed to examine range adaptation in SCZ patients and MDD patients. Fifty SCZ, 46 MDD patients and 56 controls completed the Effort-based Pleasure Experience Task to measure EV and OV adaptation. SCZ and MDD patients showed altered range adaptation, albeit in different patterns. SCZ patients exhibited over-adaptation to OV and reduced adaptation to EV. By contrast, MDD patients exhibited diminished OV adaptation but intact EV adaptation. Both OV and EV adaptation were correlated with anhedonia and amotivation in SCZ and MDD. Taken together, our findings suggest that range adaptation is altered in both SCZ and MDD patients. Associations of OV and EV adaptation with anhedonia and amotivation were consistently found in SCZ and MDD patients. Impaired range adaptation in SCZ and MDD patients may be putative neural mechanisms and potential intervention targets for anhedonia and amotivation.


Persistent Identifierhttp://hdl.handle.net/10722/339464
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.334

 

DC FieldValueLanguage
dc.contributor.authorWang, L-
dc.contributor.authorLui, SSY-
dc.contributor.authorSo, JWL-
dc.contributor.authorHu, H-
dc.contributor.authorChu, M-
dc.contributor.authorCheng, K-
dc.contributor.authorLi, S-
dc.contributor.authorLe B,-
dc.contributor.authorLv, Q-
dc.contributor.authorYi, Z-
dc.contributor.authorChan, RCK -
dc.date.accessioned2024-03-11T10:36:50Z-
dc.date.available2024-03-11T10:36:50Z-
dc.date.issued2024-02-01-
dc.identifier.citationAsian Journal of Psychiatry, 2024, v. 92-
dc.identifier.issn1876-2018-
dc.identifier.urihttp://hdl.handle.net/10722/339464-
dc.description.abstract<p>Anhedonia and amotivation are core symptoms of schizophrenia (SCZ) and major depressive disorder (MDD). Reward processing involves constructing and contrasting the representations for expected value (EV) and outcome value (OV) of a given stimulus, a phenomenon termed range adaptation. Impaired range adaptation can lead to anhedonia and amotivation. This study aimed to examine range adaptation in SCZ patients and MDD patients. Fifty SCZ, 46 MDD patients and 56 controls completed the Effort-based Pleasure Experience Task to measure EV and OV adaptation. SCZ and MDD patients showed altered range adaptation, albeit in different patterns. SCZ patients exhibited over-adaptation to OV and reduced adaptation to EV. By contrast, MDD patients exhibited diminished OV adaptation but intact EV adaptation. Both OV and EV adaptation were correlated with anhedonia and amotivation in SCZ and MDD. Taken together, our findings suggest that range adaptation is altered in both SCZ and MDD patients. Associations of OV and EV adaptation with anhedonia and amotivation were consistently found in SCZ and MDD patients. Impaired range adaptation in SCZ and MDD patients may be putative neural mechanisms and potential intervention targets for anhedonia and amotivation.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofAsian Journal of Psychiatry-
dc.titleRange adaptive value representations in schizophrenia and major depression-
dc.typeArticle-
dc.identifier.volume92-
dc.identifier.issnl1876-2018-

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