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Article: Chemotherapy-induced ovarian damage and protective strategies

TitleChemotherapy-induced ovarian damage and protective strategies
Authors
Issue Date6-Dec-2023
PublisherBritish Fertility Society
Citation
Human Fertility, 2023, v. 98 How to Cite?
Abstract

More than 9.2 million women worldwide suffer from cancer, and about 5% of them are at reproductive age. Chemotherapy-induced impairment of fertility affects the quality of life of these women. Several chemotherapeutic agents have been proven to cause apoptosis and autophagy by inducing DNA damage and cellular stress. Injuries to the ovarian stroma and micro-vessel network are also considered as pivotal factors resulting in ovarian dysfunction induced by chemotherapeutic agents. Primordial follicle pool over-activation may also be the mechanism inducing damage to the ovarian reserve. Although many studies have explored the mechanisms involved in chemotherapy-induced reproductive toxicity, the exact molecular mechanisms have not been elucidated. It is essential to understand the mechanisms involved in ovarian damage, in order to develop potential protective treatments to preserve fertility. In this article, we reviewed the current knowledge on the mechanism of chemotherapy-induced ovarian damage and possible protective strategies that prevent the ovary from such damages.


Persistent Identifierhttp://hdl.handle.net/10722/339289
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.620

 

DC FieldValueLanguage
dc.contributor.authorZhao, Peikun-
dc.contributor.authorGuo, Chenxi-
dc.contributor.authorDu Huijia,-
dc.contributor.authorXiao, Yuan-
dc.contributor.authorSu, Jiaping-
dc.contributor.authorWang, Xiaohui-
dc.contributor.authorYeung, Willian S B-
dc.contributor.authorLi, Guangxin-
dc.contributor.authorWang, Tianren-
dc.date.accessioned2024-03-11T10:35:27Z-
dc.date.available2024-03-11T10:35:27Z-
dc.date.issued2023-12-06-
dc.identifier.citationHuman Fertility, 2023, v. 98-
dc.identifier.issn1464-7273-
dc.identifier.urihttp://hdl.handle.net/10722/339289-
dc.description.abstract<p>More than 9.2 million women worldwide suffer from cancer, and about 5% of them are at reproductive age. Chemotherapy-induced impairment of fertility affects the quality of life of these women. Several chemotherapeutic agents have been proven to cause apoptosis and autophagy by inducing DNA damage and cellular stress. Injuries to the ovarian stroma and micro-vessel network are also considered as pivotal factors resulting in ovarian dysfunction induced by chemotherapeutic agents. Primordial follicle pool over-activation may also be the mechanism inducing damage to the ovarian reserve. Although many studies have explored the mechanisms involved in chemotherapy-induced reproductive toxicity, the exact molecular mechanisms have not been elucidated. It is essential to understand the mechanisms involved in ovarian damage, in order to develop potential protective treatments to preserve fertility. In this article, we reviewed the current knowledge on the mechanism of chemotherapy-induced ovarian damage and possible protective strategies that prevent the ovary from such damages.<br></p>-
dc.languageeng-
dc.publisherBritish Fertility Society-
dc.relation.ispartofHuman Fertility-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleChemotherapy-induced ovarian damage and protective strategies-
dc.typeArticle-
dc.identifier.doi10.1080/14647273.2023.2275764-
dc.identifier.volume98-
dc.identifier.eissn1742-8149-
dc.identifier.issnl1464-7273-

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