File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.7503/cjcu20220438
- Scopus: eid_2-s2.0-85159962582
- WOS: WOS:000961097600001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: In-solution Selection Methods of DNA-encoded Library (DEL)
Title | In-solution Selection Methods of DNA-encoded Library (DEL) DNA编码分子库液相筛选方法的新进展 |
---|---|
Authors | |
Keywords | DNA-encoded library Drug discovery Drug selection In-solution selection |
Issue Date | 14-Mar-2023 |
Publisher | Springer |
Citation | Chemical Research in Chinese Universities, 2022, v. 43, n. 3, p. 20220438 How to Cite? |
Abstract | DNA-encoded library(DEL) has become a nearly indispensable technology platform for the development of new drugs in the pharmaceutical industry. The DEL technology has become matured over the past three decades and the rapid development of DEL-compatible chemistries has tremendously improved the chemical diversity of DELs and promoted its application in drug discovery. DEL technology has been widely adopted by pharmaceutical companies, and numerous clinical candidates have been identified from DEL selection. Usually, the selection of DEL is mainly affinity-based selection on solid-phase. The purified target protein is immobilized on the matrix, and then the binders are separated from non-binders by physical washes. In recent years, a series of in-solution selection methods for DEL have been developed, which has further expanded the target scope suitable for DEL and revealing the potential of DEL as an effective tool to explore fundamental biology. This review mainly introduces the selection methods of DEL in-solution phase and their applications, and finally gives a brief outlook on the application of DEL technology to complex biological targets and functional selection. |
Persistent Identifier | http://hdl.handle.net/10722/339264 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.620 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Yingying | - |
dc.contributor.author | Li, Xiaomin | - |
dc.contributor.author | Cai, Yahui | - |
dc.contributor.author | Li, Xiaoyu | - |
dc.contributor.author | Shi, Bingbing | - |
dc.date.accessioned | 2024-03-11T10:35:15Z | - |
dc.date.available | 2024-03-11T10:35:15Z | - |
dc.date.issued | 2023-03-14 | - |
dc.identifier.citation | Chemical Research in Chinese Universities, 2022, v. 43, n. 3, p. 20220438 | - |
dc.identifier.issn | 1005-9040 | - |
dc.identifier.uri | http://hdl.handle.net/10722/339264 | - |
dc.description.abstract | <p>DNA-encoded library(DEL) has become a nearly indispensable technology platform for the development of new drugs in the pharmaceutical industry. The DEL technology has become matured over the past three decades and the rapid development of DEL-compatible chemistries has tremendously improved the chemical diversity of DELs and promoted its application in drug discovery. DEL technology has been widely adopted by pharmaceutical companies, and numerous clinical candidates have been identified from DEL selection. Usually, the selection of DEL is mainly affinity-based selection on solid-phase. The purified target protein is immobilized on the matrix, and then the binders are separated from non-binders by physical washes. In recent years, a series of in-solution selection methods for DEL have been developed, which has further expanded the target scope suitable for DEL and revealing the potential of DEL as an effective tool to explore fundamental biology. This review mainly introduces the selection methods of DEL in-solution phase and their applications, and finally gives a brief outlook on the application of DEL technology to complex biological targets and functional selection.<br></p> | - |
dc.language | chi | - |
dc.publisher | Springer | - |
dc.relation.ispartof | Chemical Research in Chinese Universities | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | DNA-encoded library | - |
dc.subject | Drug discovery | - |
dc.subject | Drug selection | - |
dc.subject | In-solution selection | - |
dc.title | In-solution Selection Methods of DNA-encoded Library (DEL) | - |
dc.title | DNA编码分子库液相筛选方法的新进展 | - |
dc.type | Article | - |
dc.identifier.doi | 10.7503/cjcu20220438 | - |
dc.identifier.scopus | eid_2-s2.0-85159962582 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 20220438 | - |
dc.identifier.eissn | 2210-3171 | - |
dc.identifier.isi | WOS:000961097600001 | - |
dc.identifier.issnl | 1005-9040 | - |