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Book Chapter: Tumor Microenvironment for Melanoma Cells
| Title | Tumor Microenvironment for Melanoma Cells |
|---|---|
| Authors | |
| Issue Date | 18-May-2011 |
| Publisher | Springer Vienna |
| Abstract | Melanoma represents an ideal experimental system to model the influence of tumor microenvironment on neoplastic cells given that a rich collection of cell types is localized in the physiological environment. Melanoma cells actively interact with the tumor microenvironment in a bidirectional manner by orchestrating the normal cells. Human epidermal melanocytes can readily be isolated and used as a paradigm to understand initiation and development of their malignant counterparts, melanoma cells. This chapter focuses on cell–cell communication between melanocytes and surrounding keratinocytes and fibroblasts, and summarizes key growth factors and inflammatory cytokines that are important for melanocyte function and homeostasis. We will then propose a model of malignant transformation of melanocytes, in which microenvironmental signals play key roles. |
| Persistent Identifier | http://hdl.handle.net/10722/339176 |
| ISBN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, Gao | - |
| dc.contributor.author | Herlyn, Meenhard | - |
| dc.date.accessioned | 2024-03-11T10:34:27Z | - |
| dc.date.available | 2024-03-11T10:34:27Z | - |
| dc.date.issued | 2011-05-18 | - |
| dc.identifier.isbn | 9783709103708 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/339176 | - |
| dc.description.abstract | <p>Melanoma represents an ideal experimental system to model the influence of tumor microenvironment on neoplastic cells given that a rich collection of cell types is localized in the physiological environment. Melanoma cells actively interact with the tumor microenvironment in a bidirectional manner by orchestrating the normal cells. Human epidermal melanocytes can readily be isolated and used as a paradigm to understand initiation and development of their malignant counterparts, melanoma cells. This chapter focuses on cell–cell communication between melanocytes and surrounding keratinocytes and fibroblasts, and summarizes key growth factors and inflammatory cytokines that are important for melanocyte function and homeostasis. We will then propose a model of malignant transformation of melanocytes, in which microenvironmental signals play key roles.</p> | - |
| dc.language | eng | - |
| dc.publisher | Springer Vienna | - |
| dc.relation.ispartof | Melanoma Development. | - |
| dc.title | Tumor Microenvironment for Melanoma Cells | - |
| dc.type | Book_Chapter | - |
| dc.identifier.doi | 10.1007/978-3-7091-0371-5_14 | - |
| dc.identifier.eisbn | 9783709103715 | - |