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Article: Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway
| Title | Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway |
|---|---|
| Authors | |
| Keywords | Lipogenesis Natural product Proteomic and metabolomic analysis Spatholobi suberectus Therapy TNBC |
| Issue Date | 6-Nov-2023 |
| Publisher | Elsevier |
| Citation | Journal of Traditional and Complementary Medicine, 2023, v. 13, n. 6, p. 623-638 How to Cite? |
| Abstract | Background and aimTriple-negative breast cancer (TNBC) is a highly invasive type of breast cancer with a poor prognosis. Currently, there are no effective management strategies for TNBC. Earlier, our lab reported the percolation of Spatholobus suberectus for the treatment of breast cancer. Lipid metabolic reprogramming is a hallmark of cancer. However, the anti-TNBC efficiency of S. suberectus extract and its causal mechanism for preventing lipogenesis have not been fully recognized. Hence, the present study aimed to investigate the inhibitory role of S. suberectus extract on lipogenesis and tumorigenesis in TNBC in vitro and in vivo by activating AMPK-ACC and K-Ras-ERK signaling pathways using lipidomic and metabolomic techniques. Experimental procedureDried stems of S. suberectus extract inhibited lipogenesis and tumorigenesis and promoted fatty acid oxidation as demonstrated by the identification of the metabolites and fatty acid markers using proteomic and metabolomic analysis, qPCR, and Western blot. Results and conclusionThe results indicated that S. suberectus extract promotes fatty acid oxidation and suppresses lipogenic metabolites and biomarkers, thereby preventing tumorigenesis via the AMPK-ACC and K-Ras-ERK signaling pathways. On the basis of this preclinical evidence, we suggest that this study represents a milestone and complements Chinese medicine. Further studies remain underway in our laboratory to elucidate the active principles of S. suberectus extract. This study suggests that S. suberectus extract could be a promising therapy for TNBC. |
| Persistent Identifier | http://hdl.handle.net/10722/339097 |
| ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.687 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zeng, Xiaohui | - |
| dc.contributor.author | Gong, Guowei | - |
| dc.contributor.author | Ganesan, Kumar | - |
| dc.contributor.author | Wen, Yi | - |
| dc.contributor.author | Liu, Qingqing | - |
| dc.contributor.author | Zhuo, Juncheng | - |
| dc.contributor.author | Wu, Jianming | - |
| dc.contributor.author | Chen, Jianping | - |
| dc.date.accessioned | 2024-03-11T10:33:53Z | - |
| dc.date.available | 2024-03-11T10:33:53Z | - |
| dc.date.issued | 2023-11-06 | - |
| dc.identifier.citation | Journal of Traditional and Complementary Medicine, 2023, v. 13, n. 6, p. 623-638 | - |
| dc.identifier.issn | 2225-4110 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/339097 | - |
| dc.description.abstract | <h3>Background and aim</h3><p>Triple-negative breast cancer (TNBC) is a highly invasive type of breast cancer with a poor prognosis. Currently, there are no effective management strategies for TNBC. Earlier, our lab reported the percolation of <em>Spatholobus suberectus</em> for the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about treatment from ScienceDirect's AI-generated Topic Pages">treatment</a> of breast cancer. Lipid metabolic reprogramming is a hallmark of cancer. However, the anti-TNBC efficiency of <em>S. suberectus</em> extract and its causal mechanism for preventing <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lipogenesis" title="Learn more about lipogenesis from ScienceDirect's AI-generated Topic Pages">lipogenesis</a> have not been fully recognized. Hence, the present study aimed to investigate the inhibitory role of <em>S. suberectus</em> extract on lipogenesis and tumorigenesis in TNBC <em>in vitro</em> and <em>in vivo</em> by activating AMPK-ACC and K-Ras-ERK <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction" title="Learn more about signaling pathways from ScienceDirect's AI-generated Topic Pages">signaling pathways</a> using <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/lipidomics" title="Learn more about lipidomic from ScienceDirect's AI-generated Topic Pages">lipidomic</a> and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolomics" title="Learn more about metabolomic from ScienceDirect's AI-generated Topic Pages">metabolomic</a> techniques.</p><h3>Experimental procedure</h3><p>Dried stems of <em>S. suberectus</em> extract inhibited lipogenesis and tumorigenesis and promoted <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/fatty-acid-oxidation" title="Learn more about fatty acid oxidation from ScienceDirect's AI-generated Topic Pages">fatty acid oxidation</a> as demonstrated by the identification of the metabolites and fatty acid markers using <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/proteomics" title="Learn more about proteomic from ScienceDirect's AI-generated Topic Pages">proteomic</a> and metabolomic analysis, qPCR, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/western-blot" title="Learn more about Western blot from ScienceDirect's AI-generated Topic Pages">Western blot</a>.</p><h3>Results and conclusion</h3><p>The results indicated that <em>S. suberectus</em> extract promotes fatty acid oxidation and suppresses lipogenic metabolites and biomarkers, thereby preventing tumorigenesis via the AMPK-ACC and K-Ras-ERK signaling pathways. On the basis of this preclinical evidence, we suggest that this study represents a milestone and complements <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/traditional-chinese-medicine" title="Learn more about Chinese medicine from ScienceDirect's AI-generated Topic Pages">Chinese medicine</a>. Further studies remain underway in our laboratory to elucidate the active principles of <em>S. suberectus</em> extract. This study suggests that <em>S. suberectus</em> extract could be a promising therapy for TNBC.</p> | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation.ispartof | Journal of Traditional and Complementary Medicine | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Lipogenesis | - |
| dc.subject | Natural product | - |
| dc.subject | Proteomic and metabolomic analysis | - |
| dc.subject | Spatholobi suberectus | - |
| dc.subject | Therapy | - |
| dc.subject | TNBC | - |
| dc.title | Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1016/j.jtcme.2023.09.002 | - |
| dc.identifier.scopus | eid_2-s2.0-85171526770 | - |
| dc.identifier.volume | 13 | - |
| dc.identifier.issue | 6 | - |
| dc.identifier.spage | 623 | - |
| dc.identifier.epage | 638 | - |
| dc.identifier.isi | WOS:001109600800001 | - |
| dc.identifier.issnl | 2225-4110 | - |