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Article: Unveiling the immune system ageing in single-cell resolution
Title | Unveiling the immune system ageing in single-cell resolution |
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Authors | |
Issue Date | 2-Nov-2023 |
Publisher | Oxford University Press |
Citation | Journal of Leukocyte Biology, 2023 How to Cite? |
Abstract | This writing serves as a commentary on the findings presented in the original manuscript by Yang et al. in 2023, published in the Journal of Leukocyte Biology (JLB). This commentary first summarizes the spatial-temporal dynamics of regulatory T-cells (T-reg) derived from mice (Tabula Muris Senis) of different ages (3M, 18M, and 24M) at different anatomical niches like lymph nodes and bone marrow. We also reported possible combinations of receptor-ligand interactions among T follicular regulatory cells (Tfr), T follicular helper cells (Tfr), and Germinal Centre (GC) B-cells, such as Calmodulin/Fas axis and PSGL-1/L-selectin axis. Then, we have elaborated on the significance of understanding aging T-reg, and have offered some possible future research directions for Yang et al., contributing to a critical analysis of their recent study. Building upon these foundations, further investigations and studies can be conducted to delve deeper into the mechanisms by which T-reg influence health upon aging, potentially unveiling novel therapeutic targets to ameliorate age-related pathogenicity. |
Persistent Identifier | http://hdl.handle.net/10722/339070 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.521 |
DC Field | Value | Language |
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dc.contributor.author | Chan, Chun Lai | - |
dc.contributor.author | Sugimura, Ryohichi | - |
dc.date.accessioned | 2024-03-11T10:33:39Z | - |
dc.date.available | 2024-03-11T10:33:39Z | - |
dc.date.issued | 2023-11-02 | - |
dc.identifier.citation | Journal of Leukocyte Biology, 2023 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | http://hdl.handle.net/10722/339070 | - |
dc.description.abstract | <p>This writing serves as a commentary on the findings presented in the original manuscript by Yang et al. in 2023, published in the Journal of Leukocyte Biology (JLB). This commentary first summarizes the spatial-temporal dynamics of regulatory T-cells (T-reg) derived from mice (<em>Tabula Muris Senis</em>) of different ages (3M, 18M, and 24M) at different anatomical niches like lymph nodes and bone marrow. We also reported possible combinations of receptor-ligand interactions among T follicular regulatory cells (Tfr), T follicular helper cells (Tfr), and Germinal Centre (GC) B-cells, such as Calmodulin/Fas axis and PSGL-1/L-selectin axis. Then, we have elaborated on the significance of understanding aging T-reg, and have offered some possible future research directions for Yang et al., contributing to a critical analysis of their recent study. Building upon these foundations, further investigations and studies can be conducted to delve deeper into the mechanisms by which T-reg influence health upon aging, potentially unveiling novel therapeutic targets to ameliorate age-related pathogenicity.</p> | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Journal of Leukocyte Biology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Unveiling the immune system ageing in single-cell resolution | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1093/jleuko/qiad136 | - |
dc.identifier.eissn | 1938-3673 | - |
dc.identifier.issnl | 0741-5400 | - |