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Article: Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

TitleIndications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma
Authors
KeywordsHepatocellular carcinoma
Inflammatory responses
Laparoscopic liver resection
Open liver resection
Postoperative cytokines
Issue Date20-Oct-2023
PublisherFirst Affilated Hospital Hospital, Zhejiang University School of Medicine
Citation
Hepatobiliary & Pancreatic Diseases International, 2023 How to Cite?
Abstract

Background

Our clinical practice of laparoscopic liver resection (LLR) had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma (HCC) over open liver resection (OLR), but the underlying mechanisms are not clear. This study was to find out whether systemic inflammation plays an important role.

Methods

A total of 103 patients with early-stage HCC under liver resection were enrolled (LLR group, n = 53; OLR group, n = 50). The expression of 9 inflammatory cytokines in patients at preoperation, postoperative day 1 (POD1) and POD7 was quantified by Luminex Multiplex assay. The relationships of the cytokines and the postoperative outcomes were compared between LLR and OLR.

Results

Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative levels. Compared to OLR, the POD1 levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) in the LLR group were significantly lower. Higher POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during operation. The levels of these cytokines were positively associated with postoperative liver injury, and the length of hospital stay. Importantly, a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver resection.

Conclusions

Significantly lower level of GM-CSF, IL-6, IL-8, and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.


Persistent Identifierhttp://hdl.handle.net/10722/339063
ISSN
2023 Impact Factor: 3.6

 

DC FieldValueLanguage
dc.contributor.authorNg, KT-
dc.contributor.authorPang, L-
dc.contributor.authorWang, JQ-
dc.contributor.authorShe, WH-
dc.contributor.authorTsang, SH-
dc.contributor.authorLo, CM-
dc.contributor.authorMan, K-
dc.contributor.authorCheung, TT-
dc.date.accessioned2024-03-11T10:33:35Z-
dc.date.available2024-03-11T10:33:35Z-
dc.date.issued2023-10-20-
dc.identifier.citationHepatobiliary & Pancreatic Diseases International, 2023-
dc.identifier.issn2352-9377-
dc.identifier.urihttp://hdl.handle.net/10722/339063-
dc.description.abstract<h3>Background</h3><p>Our clinical practice of laparoscopic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hepatectomy" title="Learn more about liver resection from ScienceDirect's AI-generated Topic Pages">liver resection</a> (LLR) had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma (HCC) over open <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hepatectomy" title="Learn more about liver resection from ScienceDirect's AI-generated Topic Pages">liver resection</a> (OLR), but the underlying mechanisms are not clear. This study was to find out whether systemic inflammation plays an important role.</p><h3>Methods</h3><p>A total of 103 patients with early-stage HCC under liver resection were enrolled (LLR group, <em>n</em> = 53; OLR group, <em>n</em> = 50). The expression of 9 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/inflammatory-cytokine" title="Learn more about inflammatory cytokines from ScienceDirect's AI-generated Topic Pages">inflammatory cytokines</a> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/inpatient" title="Learn more about in patients from ScienceDirect's AI-generated Topic Pages">in patients</a> at preoperation, postoperative day 1 (POD1) and POD7 was quantified by Luminex Multiplex assay. The relationships of the cytokines and the postoperative outcomes were compared between LLR and OLR.</p><h3>Results</h3><p>Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative levels. Compared to OLR, the POD1 levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) in the LLR group were significantly lower. Higher POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during operation. The levels of these cytokines were positively associated with postoperative liver injury, and the length of hospital stay. Importantly, a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver resection.</p><h3>Conclusions</h3><p>Significantly lower level of GM-CSF, IL-6, IL-8, and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.</p>-
dc.languageeng-
dc.publisherFirst Affilated Hospital Hospital, Zhejiang University School of Medicine-
dc.relation.ispartofHepatobiliary & Pancreatic Diseases International-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHepatocellular carcinoma-
dc.subjectInflammatory responses-
dc.subjectLaparoscopic liver resection-
dc.subjectOpen liver resection-
dc.subjectPostoperative cytokines-
dc.titleIndications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.doi10.1016/j.hbpd.2023.10.006-
dc.identifier.scopuseid_2-s2.0-85175064547-
dc.identifier.issnl2352-9377-

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