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Article: Development and validation of bone-suppressed deep learning classification of COVID-19 presentation in chest radiographs

TitleDevelopment and validation of bone-suppressed deep learning classification of COVID-19 presentation in chest radiographs
Authors
Keywordsbone suppression
chest radiography
Classification
coronavirus disease 2019 (COVID-19)
deep learning
Issue Date1-Jul-2022
PublisherAME Publishing
Citation
Quantitative Imaging in Medicine and Surgery, 2022, v. 12, n. 7, p. 3917-3931 How to Cite?
Abstract

Background: Coronavirus disease 2019 (COVID-19) is a pandemic disease. Fast and accurate diagnosis of COVID-19 from chest radiography may enable more efficient allocation of scarce medical resources and hence improved patient outcomes. Deep learning classification of chest radiographs may be a plausible step towards this. We hypothesize that bone suppression of chest radiographs may improve the performance of deep learning classification of COVID-19 phenomena in chest radiographs.

Methods: Two bone suppression methods (Gusarev et al. and Rajaraman et al.) were implemented. The Gusarev and Rajaraman methods were trained on 217 pairs of normal and bone-suppressed chest radiographs from the X-ray Bone Shadow Suppression dataset (https://www.kaggle.com/hmchuong/xray-bone-shadow-supression). Two classifier methods with different network architectures were implemented. Binary classifier models were trained on the public RICORD-1c and RSNA Pneumonia Challenge datasets. An external test dataset was created retrospectively from a set of 320 COVID-19 positive patients from Queen Elizabeth Hospital (Hong Kong, China) and a set of 518 non-COVID-19 patients from Pamela Youde Nethersole Eastern Hospital (Hong Kong, China), and used to evaluate the effect of bone suppression on classifier performance. Classification performance, quantified by sensitivity, specificity, negative predictive value (NPV), accuracy and area under the receiver operating curve (AUC), for non-suppressed radiographs was compared to that for bone suppressed radiographs. Some of the pre-trained models used in this study are published at (https://github.com/danielnflam).

Results: Bone suppression of external test data was found to significantly (P<0.05) improve AUC for one classifier architecture [from 0.698 (non-suppressed) to 0.732 (Rajaraman-suppressed)]. For the other classifier architecture, suppression did not significantly (P>0.05) improve or worsen classifier performance.

Conclusions: Rajaraman suppression significantly improved classification performance in one classification architecture, and did not significantly worsen classifier performance in the other classifier architecture. This research could be extended to explore the impact of bone suppression on classification of different lung pathologies, and the effect of other image enhancement techniques on classifier performance.


Persistent Identifierhttp://hdl.handle.net/10722/338912
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.746
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, NFD-
dc.contributor.authorSun, HF-
dc.contributor.authorSong, LM-
dc.contributor.authorYang, DR-
dc.contributor.authorZhi, SH-
dc.contributor.authorRen, G-
dc.contributor.authorChou, PH-
dc.contributor.authorWan, SBN-
dc.contributor.authorWong, MFE-
dc.contributor.authorChan, KK-
dc.contributor.authorTsang, HCH-
dc.contributor.authorKong, FM-
dc.contributor.authorWang, YXJ-
dc.contributor.authorQin, J-
dc.contributor.authorChan, LWC-
dc.contributor.authorYing, M-
dc.contributor.authorCai, J-
dc.date.accessioned2024-03-11T10:32:29Z-
dc.date.available2024-03-11T10:32:29Z-
dc.date.issued2022-07-01-
dc.identifier.citationQuantitative Imaging in Medicine and Surgery, 2022, v. 12, n. 7, p. 3917-3931-
dc.identifier.issn2223-4292-
dc.identifier.urihttp://hdl.handle.net/10722/338912-
dc.description.abstract<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) is a pandemic disease. Fast and accurate diagnosis of COVID-19 from chest radiography may enable more efficient allocation of scarce medical resources and hence improved patient outcomes. Deep learning classification of chest radiographs may be a plausible step towards this. We hypothesize that bone suppression of chest radiographs may improve the performance of deep learning classification of COVID-19 phenomena in chest radiographs.</p><p><strong>Methods: </strong>Two bone suppression methods (Gusarev <em>et al.</em> and Rajaraman <em>et al.</em>) were implemented. The Gusarev and Rajaraman methods were trained on 217 pairs of normal and bone-suppressed chest radiographs from the X-ray Bone Shadow Suppression dataset (<a href="https://www.kaggle.com/hmchuong/xray-bone-shadow-supression">https://www.kaggle.com/hmchuong/xray-bone-shadow-supression</a>). Two classifier methods with different network architectures were implemented. Binary classifier models were trained on the public RICORD-1c and RSNA Pneumonia Challenge datasets. An external test dataset was created retrospectively from a set of 320 COVID-19 positive patients from Queen Elizabeth Hospital (Hong Kong, China) and a set of 518 non-COVID-19 patients from Pamela Youde Nethersole Eastern Hospital (Hong Kong, China), and used to evaluate the effect of bone suppression on classifier performance. Classification performance, quantified by sensitivity, specificity, negative predictive value (NPV), accuracy and area under the receiver operating curve (AUC), for non-suppressed radiographs was compared to that for bone suppressed radiographs. Some of the pre-trained models used in this study are published at (<a href="https://github.com/danielnflam">https://github.com/danielnflam</a>).</p><p><strong>Results: </strong>Bone suppression of external test data was found to significantly (P<0.05) improve AUC for one classifier architecture [from 0.698 (non-suppressed) to 0.732 (Rajaraman-suppressed)]. For the other classifier architecture, suppression did not significantly (P>0.05) improve or worsen classifier performance.</p><p><strong>Conclusions: </strong>Rajaraman suppression significantly improved classification performance in one classification architecture, and did not significantly worsen classifier performance in the other classifier architecture. This research could be extended to explore the impact of bone suppression on classification of different lung pathologies, and the effect of other image enhancement techniques on classifier performance.</p>-
dc.languageeng-
dc.publisherAME Publishing-
dc.relation.ispartofQuantitative Imaging in Medicine and Surgery-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbone suppression-
dc.subjectchest radiography-
dc.subjectClassification-
dc.subjectcoronavirus disease 2019 (COVID-19)-
dc.subjectdeep learning-
dc.titleDevelopment and validation of bone-suppressed deep learning classification of COVID-19 presentation in chest radiographs-
dc.typeArticle-
dc.identifier.doi10.21037/qims-21-791-
dc.identifier.scopuseid_2-s2.0-85131331712-
dc.identifier.volume12-
dc.identifier.issue7-
dc.identifier.spage3917-
dc.identifier.epage3931-
dc.identifier.eissn2223-4306-
dc.identifier.isiWOS:000803256300001-
dc.identifier.issnl2223-4306-

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