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Article: Quantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients

TitleQuantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients
Authors
Keywordslymph node tumor
N stage
nasopharyngeal carcinoma
tumor geometry
Issue Date30-Dec-2022
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Citation
Cancers, 2022, v. 15, n. 1 How to Cite?
Abstract

This study aims to investigate the feasibility of improving the prognosis stratification of the N staging system of Nasopharyngeal Carcinoma (NPC) from quantitative spatial characterizations of metastatic lymph node (LN) for NPC in a multi-institutional setting. A total of 194 and 284 NPC patients were included from two local hospitals as the discovery and validation cohort. Spatial relationships between LN and the surrounding organs were quantified by both distance and angle histograms, followed by principal component analysis. Independent prognostic factors were identified and combined with the N stage into a new prognostic index by univariate and multivariate Cox regressions on disease-free survival (DFS). The new three-class risk stratification based on the constructed prognostic index demonstrated superior cross-institutional performance in DFS. The hazard ratios of the high-risk to low-risk group were 9.07 (p < 0.001) and 4.02 (p < 0.001) on training and validation, respectively, compared with 5.19 (p < 0.001) and 1.82 (p = 0.171) of N3 to N1. Our spatial characterizations of lymph node tumor anatomy improved the existing N-stage in NPC prognosis. Our quantitative approach may facilitate the discovery of new anatomical characteristics to improve patient staging in other diseases.


Persistent Identifierhttp://hdl.handle.net/10722/338911
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.391
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, J-
dc.contributor.authorTeng, XZ-
dc.contributor.authorLam, S-
dc.contributor.authorSun, JC-
dc.contributor.authorCheung, ALY-
dc.contributor.authorNg, SCY-
dc.contributor.authorLee, FKH-
dc.contributor.authorAu, KH-
dc.contributor.authorYip, CWY-
dc.contributor.authorLee, VHF-
dc.contributor.authorLin, ZS-
dc.contributor.authorLiang, YY-
dc.contributor.authorYang, RJ-
dc.contributor.authorHan, Y-
dc.contributor.authorZhang, YP-
dc.contributor.authorKong, FM-
dc.contributor.authorCai, J-
dc.date.accessioned2024-03-11T10:32:28Z-
dc.date.available2024-03-11T10:32:28Z-
dc.date.issued2022-12-30-
dc.identifier.citationCancers, 2022, v. 15, n. 1-
dc.identifier.issn2072-6694-
dc.identifier.urihttp://hdl.handle.net/10722/338911-
dc.description.abstract<p>This study aims to investigate the feasibility of improving the prognosis stratification of the N staging system of Nasopharyngeal Carcinoma (NPC) from quantitative spatial characterizations of metastatic lymph node (LN) for NPC in a multi-institutional setting. A total of 194 and 284 NPC patients were included from two local hospitals as the discovery and validation cohort. Spatial relationships between LN and the surrounding organs were quantified by both distance and angle histograms, followed by principal component analysis. Independent prognostic factors were identified and combined with the N stage into a new prognostic index by univariate and multivariate Cox regressions on disease-free survival (DFS). The new three-class risk stratification based on the constructed prognostic index demonstrated superior cross-institutional performance in DFS. The hazard ratios of the high-risk to low-risk group were 9.07 (p < 0.001) and 4.02 (p < 0.001) on training and validation, respectively, compared with 5.19 (p < 0.001) and 1.82 (p = 0.171) of N3 to N1. Our spatial characterizations of lymph node tumor anatomy improved the existing N-stage in NPC prognosis. Our quantitative approach may facilitate the discovery of new anatomical characteristics to improve patient staging in other diseases.</p>-
dc.languageeng-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.relation.ispartofCancers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectlymph node tumor-
dc.subjectN stage-
dc.subjectnasopharyngeal carcinoma-
dc.subjecttumor geometry-
dc.titleQuantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients-
dc.typeArticle-
dc.identifier.doi10.3390/cancers15010230-
dc.identifier.scopuseid_2-s2.0-85145993783-
dc.identifier.volume15-
dc.identifier.issue1-
dc.identifier.isiWOS:000909580500001-
dc.identifier.issnl2072-6694-

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