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Article: The predictive role of soluble programmed death ligand 1 in digestive system cancers

TitleThe predictive role of soluble programmed death ligand 1 in digestive system cancers
Authors
Keywordsdigestive system cancers
gastric cancer
overall survival
prognosis
soluble programmed death ligand 1
Issue Date13-Jul-2023
PublisherFrontiers Media
Citation
Frontiers in Oncology, 2023, v. 13 How to Cite?
Abstract

Introduction: The prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.

Methods: Comprehensive searches were run on the electronic databases (PubMed, Web of Science, EMBASE, and the Cochrane Library) to identify studies that assessed the prognostic role of sPD-L1 in DSCs. Review Manager software (version 5.3) was used for all analyses. Pooled data for survival outcomes were measured as hazard ratios (HRs), 95% confidence intervals (CIs), and odds ratios and their 95% CIs.

Results: The search identified 18 studies involving 2,070 patients with DSCs. The meta-outcome revealed that a high level of sPD-L1 was related to poorer overall survival (HR, 3.06; 95% CI: 2.22–4.22, p<0.001) and disease-free survival (HR, 2.53; 95% CI: 1.67–3.83, p<0.001) in DSCs. Individually, the prognostic significance of high level of sPD-L1 expression was the highest in hepatic cell carcinoma (HR, 4.76; p<0.001) followed by gastric cancer (HR=3.55, p<0.001).

Conclusion: sPD-L1 may be a prognostic factor in DSCs for overall survival and disease-free survival. Inflammatory cytokines, treatment approaches, and other factors may affect the expression of sPD-L1. Therefore, the prognostic value of sPD-L1 for recurrence and metastasis should be further investigated. sPD-L1 may also predict response to treatment. Well-designed prospective studies with standard assessment methods should be conducted to determine the prognostic value of sPD-L1 in DSCs.


Persistent Identifierhttp://hdl.handle.net/10722/338903
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.066
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRuan, J-
dc.contributor.authorZhao, ZH-
dc.contributor.authorQian, YT-
dc.contributor.authorXu, RL-
dc.contributor.authorLiao, GX-
dc.contributor.authorKong, FM-
dc.date.accessioned2024-03-11T10:32:24Z-
dc.date.available2024-03-11T10:32:24Z-
dc.date.issued2023-07-13-
dc.identifier.citationFrontiers in Oncology, 2023, v. 13-
dc.identifier.issn2234-943X-
dc.identifier.urihttp://hdl.handle.net/10722/338903-
dc.description.abstract<p><strong>Introduction:</strong> The prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.</p><p><strong>Methods:</strong> Comprehensive searches were run on the electronic databases (PubMed, Web of Science, EMBASE, and the Cochrane Library) to identify studies that assessed the prognostic role of sPD-L1 in DSCs. Review Manager software (version 5.3) was used for all analyses. Pooled data for survival outcomes were measured as hazard ratios (HRs), 95% confidence intervals (CIs), and odds ratios and their 95% CIs.</p><p><strong>Results:</strong> The search identified 18 studies involving 2,070 patients with DSCs. The meta-outcome revealed that a high level of sPD-L1 was related to poorer overall survival (HR, 3.06; 95% CI: 2.22–4.22, p<0.001) and disease-free survival (HR, 2.53; 95% CI: 1.67–3.83, p<0.001) in DSCs. Individually, the prognostic significance of high level of sPD-L1 expression was the highest in hepatic cell carcinoma (HR, 4.76; p<0.001) followed by gastric cancer (HR=3.55, p<0.001).</p><p><strong>Conclusion:</strong> sPD-L1 may be a prognostic factor in DSCs for overall survival and disease-free survival. Inflammatory cytokines, treatment approaches, and other factors may affect the expression of sPD-L1. Therefore, the prognostic value of sPD-L1 for recurrence and metastasis should be further investigated. sPD-L1 may also predict response to treatment. Well-designed prospective studies with standard assessment methods should be conducted to determine the prognostic value of sPD-L1 in DSCs.</p>-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdigestive system cancers-
dc.subjectgastric cancer-
dc.subjectoverall survival-
dc.subjectprognosis-
dc.subjectsoluble programmed death ligand 1-
dc.titleThe predictive role of soluble programmed death ligand 1 in digestive system cancers-
dc.typeArticle-
dc.identifier.doi10.3389/fonc.2023.1170220-
dc.identifier.scopuseid_2-s2.0-85166382108-
dc.identifier.volume13-
dc.identifier.eissn2234-943X-
dc.identifier.isiWOS:001034166900001-
dc.identifier.issnl2234-943X-

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